BR1BC_LITBE
ID BR1BC_LITBE Reviewed; 24 AA.
AC P82835;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Brevinin-1Bc;
OS Lithobates berlandieri (Rio Grande leopard frog) (Rana berlandieri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=30360;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion;
RX PubMed=10651828; DOI=10.1046/j.1432-1327.2000.01074.x;
RA Goraya J., Wang Y., Li Z., O'Flaherty M., Knoop F.C., Platz J.E.,
RA Conlon J.M.;
RT "Peptides with antimicrobial activity from four different families isolated
RT from the skins of the North American frogs Rana luteiventris, Rana
RT berlandieri and Rana pipiens.";
RL Eur. J. Biochem. 267:894-900(2000).
CC -!- FUNCTION: Antibacterial activity against Gram-positive bacterium
CC S.aureus. {ECO:0000269|PubMed:10651828}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- MASS SPECTROMETRY: Mass=2611.3; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:10651828};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P82835; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR012520; Antimicrobial_frog_1.
DR Pfam; PF08018; Antimicrobial_1; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..24
FT /note="Brevinin-1Bc"
FT /id="PRO_0000043528"
FT DISULFID 18..24
FT /evidence="ECO:0000250"
SQ SEQUENCE 24 AA; 2613 MW; DA535A4544471DF4 CRC64;
FLPFIAGVAA KFLPKIFCAI SKKC