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TCPI_VIBC3
ID   TCPI_VIBC3              Reviewed;         620 AA.
AC   A5F389; C3LYJ0; P29486; Q9KTR5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein I;
DE   AltName: Full=TCP pilus biosynthesis protein TcpI;
GN   Name=tcpI; Synonyms=tagB; OrderedLocusNames=VC0395_A0350, VC395_0841;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8005659; DOI=10.1128/iai.62.7.2669-2678.1994;
RA   Harkey C.W., Everiss K.D., Peterson K.M.;
RT   "The Vibrio cholerae toxin-coregulated-pilus gene tcpI encodes a homolog of
RT   methyl-accepting chemotaxis proteins.";
RL   Infect. Immun. 62:2669-2678(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: May function as an environmental regulator of TCP biogenesis.
CC       Negatively regulates the synthesis of the major pilin subunit of TCP
CC       (TcpA).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; L25659; AAA21729.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ22151.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP08856.1; -; Genomic_DNA.
DR   RefSeq; WP_000591846.1; NZ_JAACZH010000023.1.
DR   AlphaFoldDB; A5F389; -.
DR   SMR; A5F389; -.
DR   STRING; 345073.VC395_0841; -.
DR   EnsemblBacteria; ABQ22151; ABQ22151; VC0395_A0350.
DR   KEGG; vco:VC0395_A0350; -.
DR   KEGG; vcr:VC395_0841; -.
DR   PATRIC; fig|345073.21.peg.813; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_19_6; -.
DR   OMA; KEMKREW; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF103190; SSF103190; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Methylation; Transducer.
FT   CHAIN           1..620
FT                   /note="Toxin coregulated pilus biosynthesis protein I"
FT                   /id="PRO_0000321861"
FT   DOMAIN          344..580
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
SQ   SEQUENCE   620 AA;  69030 MW;  401A5187BAB368F4 CRC64;
     MIKKIISVFL LLACIITSAF TAFFYHSKLS DQTKSISSLS SQQAQERLQS YQDSLDFYKK
     LNISLSVAIA NSLRDKAVEE LNAIALRIQE NHGFIGVTFA SLDGTMFTDI GTLDWNAKTL
     RRDWFVKTVE LGTKHYTAFD IDKTTGQHVL TIATPVYVGN DIVGSVALDI AGDQIASPNG
     SGMFMMTDRN FNVFASDLTH STLIGKDLTK EKPLFKNLVS GQYVTFSDAD SHWFAVSQTE
     IDGENKLFTI IDIQQIVQTY KRDIQLIIAG FSGFSCVMLI GLYWVLSKEL SGVRQIREWI
     LSLSDGQIKE RRPIKFHNEL DTIAQSLENL QFRLLDVVRN SHRTMNDLSI KQTDITYSIE
     GNTNNSQQEL GLIEQVATAT TQLSCTSFDV MQQAQSAELN AETAQKLIAE SHDIIDSSSK
     QTEMVTLSIH ESQQIINQLR EFSDNISSVT DVINNISDQT NLLALNAAIE AARAGEQGRG
     FAVVADEVRS LAVKTQQSTI DIQGIILKLQ EQSQLADQVM TRNVSLIHET QVANRALIAS
     FNLISDKVLE ISNINSIVST AANEQKIVTE DVAKQMEDIR YLVQENLSAM ERTKQANQNI
     SDLTTNLNDA LSFFKIELTS
 
 
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