TCPN_VIBC3
ID TCPN_VIBC3 Reviewed; 276 AA.
AC A5F384; C3LYK3; P29492; Q9KTQ8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=TCP pilus virulence regulatory protein;
GN Name=tcpN; Synonyms=toxT; OrderedLocusNames=VC0395_A0363, VC395_0854;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11179381; DOI=10.1128/iai.69.3.1947-1952.2001;
RA Karaolis D.K.R., Lan R., Kaper J.B., Reeves P.R.;
RT "Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh
RT pandemic strains.";
RL Infect. Immun. 69:1947-1952(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Probable regulatory protein for the tcp operon.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF325733; AAK20765.1; -; Genomic_DNA.
DR EMBL; CP000627; ABQ20018.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP08869.1; -; Genomic_DNA.
DR RefSeq; WP_000579582.1; NZ_JAACZH010000023.1.
DR PDB; 3GBG; X-ray; 1.90 A; A=1-276.
DR PDB; 5SUW; X-ray; 2.30 A; A=1-276.
DR PDBsum; 3GBG; -.
DR PDBsum; 5SUW; -.
DR AlphaFoldDB; A5F384; -.
DR SMR; A5F384; -.
DR STRING; 345073.VC395_0854; -.
DR ChEMBL; CHEMBL4105813; -.
DR EnsemblBacteria; ABQ20018; ABQ20018; VC0395_A0363.
DR GeneID; 57739540; -.
DR KEGG; vco:VC0395_A0363; -.
DR KEGG; vcr:VC395_0854; -.
DR PATRIC; fig|345073.21.peg.826; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_1004526_0_0_6; -.
DR OMA; EIDECIV; -.
DR EvolutionaryTrace; A5F384; -.
DR Proteomes; UP000000249; Chromosome 2.
DR CollecTF; EXPREG_00000240; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR GO; GO:0001217; F:DNA-binding transcription repressor activity; IMP:CollecTF.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CollecTF.
DR DisProt; DP01439; -.
DR Gene3D; 1.10.10.1310; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR044875; ToxT_HTH1.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF00165; HTH_AraC; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Cytoplasm; DNA-binding; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..276
FT /note="TCP pilus virulence regulatory protein"
FT /id="PRO_0000321859"
FT DOMAIN 172..269
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 189..210
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 236..259
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT STRAND 7..14
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 19..26
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 31..38
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 40..44
FT /evidence="ECO:0007829|PDB:3GBG"
FT TURN 45..48
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 49..53
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 57..61
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 66..73
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 79..86
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 99..101
FT /evidence="ECO:0007829|PDB:5SUW"
FT HELIX 102..105
FT /evidence="ECO:0007829|PDB:5SUW"
FT STRAND 114..118
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 123..131
FT /evidence="ECO:0007829|PDB:3GBG"
FT TURN 132..134
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 141..155
FT /evidence="ECO:0007829|PDB:3GBG"
FT TURN 156..158
FT /evidence="ECO:0007829|PDB:3GBG"
FT STRAND 159..161
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 170..180
FT /evidence="ECO:0007829|PDB:3GBG"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 188..195
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 199..207
FT /evidence="ECO:0007829|PDB:3GBG"
FT TURN 208..210
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 213..230
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 236..242
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 248..259
FT /evidence="ECO:0007829|PDB:3GBG"
FT HELIX 263..269
FT /evidence="ECO:0007829|PDB:3GBG"
SQ SEQUENCE 276 AA; 32055 MW; 0702B68C99680757 CRC64;
MIGKKSFQTN VYRMSKFDTY IFNNLYINDY KMFWIDSGIA KLIDKNCLVS YEINSSSIIL
LKKNSIQRFS LTSLSDENIN VSVITISDSF IRSLKSYILG DLMIRNLYSE NKDLLLWNCE
HNDIAVLSEV VNGFREINYS DEFLKVFFSG FFSKVEKKYN SIFITDDLDA MEKISCLVKS
DITRNWRWAD ICGELRTNRM ILKKELESRG VKFRELINSI RISYSISLMK TGEFKIKQIA
YQSGFASVSY FSTVFKSTMN VAPSEYLFML TGVAEK
