ID   TCPP_VIBCH              Reviewed;         221 AA.
AC   P29485; Q56663;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein P;
DE   AltName: Full=TCP pilus biosynthesis protein TcpP;
GN   Name=tcpP; OrderedLocusNames=VC_0826;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1, and El Tor H1 / Serotype O1;
RX   PubMed=8621096; DOI=10.1016/0378-1119(95)00744-x;
RA   Ogierman M.A., Voss E., Meaney C., Faast R., Attridge S.R., Manning P.A.;
RT   "Comparison of the promoter proximal regions of the toxin-co-regulated tcp
RT   gene cluster in classical and El Tor strains of Vibrio cholerae O1.";
RL   Gene 170:9-16(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Involved in TCP pilus biogenesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; X64098; CAA45453.1; -; Genomic_DNA.
DR   EMBL; X74730; CAA52743.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93989.1; -; Genomic_DNA.
DR   PIR; JC4722; JC4722.
DR   RefSeq; NP_230474.1; NC_002505.1.
DR   RefSeq; WP_000542596.1; NZ_LT906614.1.
DR   AlphaFoldDB; P29485; -.
DR   SMR; P29485; -.
DR   STRING; 243277.VC_0826; -.
DR   DNASU; 2614493; -.
DR   EnsemblBacteria; AAF93989; AAF93989; VC_0826.
DR   GeneID; 57739529; -.
DR   KEGG; vch:VC_0826; -.
DR   PATRIC; fig|243277.26.peg.787; -.
DR   eggNOG; COG3710; Bacteria.
DR   HOGENOM; CLU_1277186_0_0_6; -.
DR   OMA; TQWISNE; -.
DR   BioCyc; VCHO:VC0826-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:CACAO.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   4: Predicted;
KW   Cell membrane; DNA-binding; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="Toxin coregulated pilus biosynthesis protein P"
FT                   /id="PRO_0000072467"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        5..109
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   VARIANT         20
FT                   /note="T -> S (in strain: Z17561)"
FT   VARIANT         42..44
FT                   /note="IQT -> MQA (in strain: Z17561)"
FT   VARIANT         56
FT                   /note="A -> S (in strain: Z17561)"
FT   VARIANT         118
FT                   /note="V -> I (in strain: Z17561)"
FT   VARIANT         199
FT                   /note="T -> M (in strain: Z17561)"
SQ   SEQUENCE   221 AA;  25779 MW;  B336B7531CD3967D CRC64;
     MGYVRVIYQF PDNLWWNECT NQVYYAQDPM KPERLIGTPS IIQTKLLKIL CEYHPAPCPN
     DQIIKALWPH GFISSESLTQ AIKRTRDFLN DEHKTLIENV KLQGYRINII QVIVSENVVD
     EADCSQKKSV KERIKIEWGK INVVPYLVFS ALYVALLPVI WWSYGQWYQH ELAGITHDLR
     DLARLPGITI QKLSEQKLTF AIDQHQCSVN YEQKTLECTK N