TCPQL_HUMAN
ID TCPQL_HUMAN Reviewed; 557 AA.
AC A6NM43;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Putative T-complex protein 1 subunit theta-like 1;
GN Name=CCT8L1P; Synonyms=CCT8L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possible molecular chaperone; assists the folding of proteins
CC upon ATP hydrolysis. {ECO:0000250|UniProtKB:P40227}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
CC -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC005631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471173; EAW53969.1; -; Genomic_DNA.
DR AlphaFoldDB; A6NM43; -.
DR SMR; A6NM43; -.
DR BioMuta; HGNC:32153; -.
DR jPOST; A6NM43; -.
DR MassIVE; A6NM43; -.
DR PeptideAtlas; A6NM43; -.
DR PRIDE; A6NM43; -.
DR ProteomicsDB; 1511; -.
DR GeneCards; CCT8L1P; -.
DR HGNC; HGNC:32153; CCT8L1P.
DR neXtProt; NX_A6NM43; -.
DR InParanoid; A6NM43; -.
DR PhylomeDB; A6NM43; -.
DR Pharos; A6NM43; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NM43; protein.
DR GO; GO:0005832; C:chaperonin-containing T-complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.10.560.10; -; 1.
DR Gene3D; 3.30.260.10; -; 1.
DR Gene3D; 3.50.7.10; -; 1.
DR InterPro; IPR017998; Chaperone_TCP-1.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR027413; GROEL-like_equatorial_sf.
DR InterPro; IPR027410; TCP-1-like_intermed_sf.
DR PANTHER; PTHR11353; PTHR11353; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR PRINTS; PR00304; TCOMPLEXTCP1.
DR SUPFAM; SSF48592; SSF48592; 1.
DR SUPFAM; SSF52029; SSF52029; 1.
DR SUPFAM; SSF54849; SSF54849; 1.
PE 5: Uncertain;
KW ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT CHAIN 1..557
FT /note="Putative T-complex protein 1 subunit theta-like 1"
FT /id="PRO_0000347338"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 217
FT /note="C -> S (in dbSNP:rs6969304)"
FT /id="VAR_046039"
FT VARIANT 308
FT /note="D -> N (in dbSNP:rs12672139)"
FT /id="VAR_046040"
FT VARIANT 395
FT /note="S -> G (in dbSNP:rs6953943)"
FT /id="VAR_046041"
SQ SEQUENCE 557 AA; 59514 MW; 536C5CED92C7F708 CRC64;
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLANVIRPC YGPHGRQKFL
VTMKGETVCT GCATAILRAL ELEHPAAWLL REAAQTQAEN SGDGTAFVVL LTEALLEQAE
QLLKFGLPRP QLREAYATAT AEVLATLPSL AIQSLGPLED PSWALHSVMN THTLPPMNHL
TKLVAHACWA IKELDGSFKP ERVGVCTLHG GTLEDSCLLQ GLAISGKLCG QMAAVLSGAR
VALFACPFGP AHPNAPATAC LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
EETLTLADKY GIVVIQARSR MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV YRQELGDGLA
VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHSIDAYF QPCQDPRLIP GAGATEMALA
KMLSDKGSRL EGPNGPAFLA FARALKYLPK TLAENAGLAV SDVVAEMSGV HQGGNLLMGV
GAEGIINVAQ EGVWDTLIVK AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ QIWNPDSKKT
KKRPPPVEKK KILGMNN
