TCPR1_CHICK
ID TCPR1_CHICK Reviewed; 1173 AA.
AC E1BZR9;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein 1;
GN Name=TECPR1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Tethering factor involved in autophagy. Involved in
CC autophagosome maturation by promoting the autophagosome fusion with
CC lysosomes. Binds phosphatidylinositol-3-phosphate (PtdIns(3)P) present
CC at the surface of autophagosomes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000250}. Lysosome membrane {ECO:0000250}. Note=Localizes to
CC Lysosome membranes, and binds PtdIns(3)P at the surface of
CC autophagosome. Localizes to autolysosomes, a vesicle formed by the
CC fusion between autophagosomes and lysosomes (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: The PH domain mediates the binding to phosphatidylinositol-3-
CC phosphate (PtdIns(3)P). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TECPR1 family. {ECO:0000305}.
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DR EMBL; AADN02023905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02023906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E1BZR9; -.
DR SMR; E1BZR9; -.
DR STRING; 9031.ENSGALP00000005536; -.
DR PaxDb; E1BZR9; -.
DR VEuPathDB; HostDB:geneid_416436; -.
DR eggNOG; KOG3669; Eukaryota.
DR InParanoid; E1BZR9; -.
DR OrthoDB; 119234at2759; -.
DR PhylomeDB; E1BZR9; -.
DR TreeFam; TF323648; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000421; C:autophagosome membrane; ISS:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR GO; GO:0097352; P:autophagosome maturation; ISS:UniProtKB.
DR GO; GO:0006914; P:autophagy; ISS:UniProtKB.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF06462; Hyd_WA; 3.
DR Pfam; PF06398; Pex24p; 2.
DR Pfam; PF19193; Tectonin; 1.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane;
KW Reference proteome; Repeat.
FT CHAIN 1..1173
FT /note="Tectonin beta-propeller repeat-containing protein 1"
FT /id="PRO_0000416887"
FT REPEAT 210..239
FT /note="TECPR 1"
FT REPEAT 254..285
FT /note="TECPR 2"
FT REPEAT 301..332
FT /note="TECPR 3"
FT REPEAT 344..376
FT /note="TECPR 4"
FT DOMAIN 618..727
FT /note="PH"
FT REPEAT 739..766
FT /note="TECPR 5"
FT REPEAT 962..991
FT /note="TECPR 6"
FT REPEAT 1007..1037
FT /note="TECPR 7"
FT REPEAT 1053..1083
FT /note="TECPR 8"
FT REPEAT 1095..1135
FT /note="TECPR 9"
FT REGION 413..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 131812 MW; F78338F238420ED6 CRC64;
MSSSLLWAVD IFGRVYTLST VGQYWELCKD TQLEFKRVSA VKQCCWGIAC DHQVYTYVFS
GDVPIRYQEE TYENQRWNPV GGFCEKLMPS DRWQWSDVSG LKHQQLDSFT LPSPHWEWES
DWYVDENIGG EPTEKGGWTY AIDFPSTYTK DKKWNSCVRR RRWIRYRRYK SRDVWAKITS
HDDPERLPDP FNDISIGGWE ITDEPLGRLS VWAVSLQGRV WYRENVCHHN PEGSTWSLIS
TPGEVAQISC GSYDLLWATL WEGQAIVREG IDRNNPQGIS WSTVESPSSD NGIMHVSVGV
DVVWCITKDR KVWFRRGVNS HNPCGTSWIE MVGEMMMVNV GLNNQVWGIG CDDRTIYFRQ
GVTPSELSGK MWKAIVCGRE SDRSQTGSST SLLSAGCFFT DDIQNQTNTV IQGDADTSSD
TELSSIPTNL SSTPPMGAAA SSASSTGSQA AGAPASVTVD PLDSDQGEAP AASASDEKAH
LESRKSTNPT PSTELQWTNI DLKEAHRHAV LSVSTFTETS SLSSLGMFSV GAEEQYGADE
HPLWAWVSGG GCLVDLHSPL KWFAVPSGLS SSVQSLSLSI TPAQTAAWRK QIFQQLSERT
KRELENFRHY EQAVEQSVWV KTGMLQWWRN WKPHKWMDVR VALEQFTGSD GMRDSILFIY
YMYHEEKKYI HVFLNEVTII AEVLKEGKHS FALYTPERTK QRWPICLAAT TEQEMHDWLS
LLTMSCCESR RIQGPPSHHA IWSVSCKGDI FVSEPSPELE AEPHPMPCDQ MFWRQVGGHL
RLVECNNRGI VWGIGYDHTV WVYTGGYGGG FIQGLASSAD NIYTQSDVKC VYIYENQRWN
PVTGYSSRGL PTDRYMWSDA SGLQECTKAN TKPPSPQWSW VSDWYIDFST SGGTDREGWQ
YAADFPASYH GHKTMKDFVR RRRWARKCKI VTNGPWLEVP PVTLWDISII PSSDADDEES
VALWAISDKG DVLCRLGVTQ QNPAGTSWLH VGTDQPFVSI SVGAFFQVWA VARDGSAFYR
GSVSPKKPAG DCWYHIPSPQ KQKLKQVSVG RTSVFVLDKN GNLWYRQGIT PSYPQGSAWD
HVSNNIRKMS VGPLDQVWVI ADKVQGSHGL SCGTVCHRTG VQPMEPKGLA WDYGIGGGWE
HVTVRGNASQ APRGTVPSES PPEPMESEGR VMC
