TCPR1_XENTR
ID TCPR1_XENTR Reviewed; 1173 AA.
AC A9JRJ2; F7DTL4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein 1;
GN Name=tecpr1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tethering factor involved in autophagy. Involved in
CC autophagosome maturation by promoting the autophagosome fusion with
CC lysosomes. Binds phosphatidylinositol-3-phosphate (PtdIns(3)P) present
CC at the surface of autophagosomes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000250}. Lysosome membrane {ECO:0000250}. Note=Localizes to
CC Lysosome membranes, and binds PtdIns(3)P at the surface of
CC autophagosome. Localizes to autolysosomes, a vesicle formed by the
CC fusion between autophagosomes and lysosomes (By similarity).
CC {ECO:0000250}.
CC -!- DOMAIN: The PH domain mediates the binding to phosphatidylinositol-3-
CC phosphate (PtdIns(3)P). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TECPR1 family. {ECO:0000305}.
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DR EMBL; AAMC01007028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01007029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01007030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01007031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01007032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC155682; AAI55683.1; -; mRNA.
DR RefSeq; NP_001107288.1; NM_001113816.1.
DR RefSeq; XP_017952521.1; XM_018097032.1.
DR AlphaFoldDB; A9JRJ2; -.
DR SMR; A9JRJ2; -.
DR STRING; 8364.ENSXETP00000051840; -.
DR PaxDb; A9JRJ2; -.
DR GeneID; 100135077; -.
DR KEGG; xtr:100135077; -.
DR CTD; 25851; -.
DR Xenbase; XB-GENE-5865975; tecpr1.
DR eggNOG; KOG3669; Eukaryota.
DR HOGENOM; CLU_008303_0_0_1; -.
DR InParanoid; A9JRJ2; -.
DR OMA; CPMQISR; -.
DR OrthoDB; 119234at2759; -.
DR TreeFam; TF323648; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0000421; C:autophagosome membrane; ISS:UniProtKB.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
DR GO; GO:0097352; P:autophagosome maturation; ISS:UniProtKB.
DR GO; GO:0006914; P:autophagy; ISS:UniProtKB.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF06462; Hyd_WA; 2.
DR Pfam; PF06398; Pex24p; 2.
DR Pfam; PF19193; Tectonin; 2.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane;
KW Reference proteome; Repeat.
FT CHAIN 1..1173
FT /note="Tectonin beta-propeller repeat-containing protein 1"
FT /id="PRO_0000337064"
FT REPEAT 209..240
FT /note="TECPR 1"
FT REPEAT 254..285
FT /note="TECPR 2"
FT REPEAT 301..332
FT /note="TECPR 3"
FT REPEAT 344..376
FT /note="TECPR 4"
FT DOMAIN 609..718
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REPEAT 730..757
FT /note="TECPR 5"
FT REPEAT 952..983
FT /note="TECPR 6"
FT REPEAT 997..1028
FT /note="TECPR 7"
FT REPEAT 1043..1074
FT /note="TECPR 8"
FT REPEAT 1086..1126
FT /note="TECPR 9"
FT REGION 403..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 753..754
FT /note="VT -> LS (in Ref. 2; AAI55683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1173 AA; 131493 MW; C997F4AFCB1E3794 CRC64;
MPSTVLWATD IFGKVFTLST DGQQWAPCKN GHVEFKRVSA VRSCCWGVGC NHQIYLYVHA
SDLPIRYQEE TYENQRWNPV DGYCEKLLPS DRWQWSDVTG LRHQQLESFM LPSPHWEWES
DWYVDENIGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RRWIRYRKYK SRNTWAKIPS
HEDNKKLPDP FNDITVGGWE ITDEPVGRLS VWAASLQGKV WYREDVCQNI PEGSSWTELE
TPSEVIQISC GPNDLLWASL WEGQAMVREG INRNNPKGSS WTIVEAPTPE NGIMHVSVGV
NVVWAVTKDR KVWFRRGVNS HNPCGTGWIE MVGEMAMVDV GLNDQVFGVG YEDRAVYFRQ
GVTPSELSGK AWKSIVVPRG NERSNSESPN SLLSAGCFFG DEIKEHSDSP IPSDIESSSE
PEQSAVQENS SDSSEPADVG PSQQDEPKDE ELSAVLELDG QQKAGSSLSK DSGEDSAHSA
GPVPKAGAPK WTSIDLLEAR INPARASGDM TGLSTLGIFT AGEEESFVCE THPLWTWVSG
GGCLVESHTP LKWFTLQTGL SASMQSLSLS ITPAHTAAWR KQIFDQLSER SKRELDSFRH
YEQAVEQSVW VKTGALQWYR DWKPNKWIDV RVALEQLTGT DGSRDSILFV YYTHGEEKKY
IHIFLNEVTI LVPVANEAKH SFAIYTPEKT KQRWPIRLAA ATEQEMHDWL VLLSMSCYES
RKLQGAPSSQ AIWSVTCKGD IFVSEPKADL ESVTNGRSCD QMFWRQIGGH LRMVESSSNG
VVWGLGYDHT AWVYTGGYGG GFFPGIASST DNIFPQTDTK CVYIYENQRW NPITGYSSTG
LPTDRYMWSD ASGLQECTKT NTKPPSPQWT WVSDWYIDFN VPGGTDREGW QFAADFPASY
HGYKTIKDFV RRRRWARKCR IVTSGPWLEV PPICLWDISI SPSSGAHNSE SIALWAISNK
GDVLCRLGVT KQSPSGSSWL HVGTDQPFIS VSVGGCLQVW AIARDGSAFY RGSVSPAQPA
GDCWYHIPSP HKQKLQQVSV GHTSVFVVDE NGNLWFRHGI TPTYPQGTTW EHMSNNIRKV
SVGPLDQIWV IADKVQGSHS LSCGTVCHRL GVQPMQLKGH SWDYGIGGGW EHITVRGNRA
DMAKTLQPKE NATEKPDPQE ENGESAFSHI ANC
