ID   TCPS_VIBCH              Reviewed;         152 AA.
AC   P29484; Q9KTR1;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein S;
DE   AltName: Full=TCP pilus biosynthesis protein TcpS;
DE   Flags: Precursor;
GN   Name=tcpS; OrderedLocusNames=VC_0834;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1;
RX   PubMed=8097178; DOI=10.1016/0378-1119(93)90589-u;
RA   Ogierman M.A., Zabihi S., Mourtzios L., Manning P.A.;
RT   "Genetic organization and sequence of the promoter-distal region of the tcp
RT   gene cluster of Vibrio cholerae.";
RL   Gene 126:51-60(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: The toxin coregulated pilus (TCP) is essential for successful
CC       colonization of the small intestine.
CC   -!- SUBCELLULAR LOCATION: Periplasm. Secreted.
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DR   EMBL; X64098; CAA45461.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93997.1; -; Genomic_DNA.
DR   PIR; E82275; E82275.
DR   RefSeq; NP_230482.1; NC_002505.1.
DR   RefSeq; WP_001022338.1; NZ_LT906614.1.
DR   AlphaFoldDB; P29484; -.
DR   STRING; 243277.VC_0834; -.
DR   DNASU; 2614501; -.
DR   EnsemblBacteria; AAF93997; AAF93997; VC_0834.
DR   GeneID; 57739536; -.
DR   KEGG; vch:VC_0834; -.
DR   PATRIC; fig|243277.26.peg.795; -.
DR   HOGENOM; CLU_1721585_0_0_6; -.
DR   OMA; KYILIFC; -.
DR   BioCyc; VCHO:VC0834-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020213; Toxin-coreg_pilus_synth_TcpS.
DR   Pfam; PF17456; TcpS; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..152
FT                   /note="Toxin coregulated pilus biosynthesis protein S"
FT                   /id="PRO_0000022478"
FT   CONFLICT        143
FT                   /note="S -> F (in Ref. 1; CAA45461)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   152 AA;  17357 MW;  D19D6C715EFF9969 CRC64;
     MNIKLSFISI AFLSLSFNVA ANEFEKSQEH YKSVTDLKNK IEILELEKKI TELSGEIRNA
     RMPKIDKSAP VLSPQPVVKS SEELQKSIEH IEEELKVELA YLVNNGQQKK YTFNLNGKLI
     TLVNGDFVNG WKFIEDQNKI QFSKGNKVID VN