ID   TCPZA_ARATH             Reviewed;         535 AA.
AC   Q9M888; Q8LFN3; Q94EZ9;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=T-complex protein 1 subunit zeta 1 {ECO:0000303|PubMed:11599560};
DE            Short=TCP-1-zeta 1 {ECO:0000303|PubMed:11599560};
DE   AltName: Full=CCT-zeta 1 {ECO:0000303|PubMed:11599560};
DE   AltName: Full=Chaperonin CCT6A {ECO:0000305};
GN   Name=CCT6A {ECO:0000305};
GN   OrderedLocusNames=At3g02530 {ECO:0000312|Araport:AT3G02530};
GN   ORFNames=F16B3.16 {ECO:0000312|EMBL:AAF32460.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, NOMENCLATURE, AND SUBUNIT.
RX   PubMed=11599560; DOI=10.1379/1466-1268(2001)006<0190:attiai>2.0.co;2;
RA   Hill J.E., Hemmingsen S.M.;
RT   "Arabidopsis thaliana type I and II chaperonins.";
RL   Cell Stress Chaperones 6:190-200(2001).
CC   -!- FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP
CC       hydrolysis. Known to play a role, in vitro, in the folding of actin and
CC       tubulin. {ECO:0000305}.
CC   -!- SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms
CC       two stacked rings, 12 to 16 nm in diameter.
CC       {ECO:0000305|PubMed:11599560}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family.
CC       {ECO:0000255|RuleBase:RU004187}.
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DR   EMBL; AC021640; AAF32460.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE73823.1; -; Genomic_DNA.
DR   EMBL; AY062729; AAL32807.1; -; mRNA.
DR   EMBL; AY114652; AAM47971.1; -; mRNA.
DR   EMBL; BT001156; AAN65043.1; -; mRNA.
DR   EMBL; AF387003; AAK62448.1; -; mRNA.
DR   EMBL; AY084739; AAM61312.1; -; mRNA.
DR   RefSeq; NP_186902.1; NM_111120.3.
DR   AlphaFoldDB; Q9M888; -.
DR   SMR; Q9M888; -.
DR   IntAct; Q9M888; 3.
DR   STRING; 3702.AT3G02530.1; -.
DR   MetOSite; Q9M888; -.
DR   PaxDb; Q9M888; -.
DR   PRIDE; Q9M888; -.
DR   ProteomicsDB; 234382; -.
DR   EnsemblPlants; AT3G02530.1; AT3G02530.1; AT3G02530.
DR   GeneID; 821160; -.
DR   Gramene; AT3G02530.1; AT3G02530.1; AT3G02530.
DR   KEGG; ath:AT3G02530; -.
DR   Araport; AT3G02530; -.
DR   TAIR; locus:2076924; AT3G02530.
DR   eggNOG; KOG0359; Eukaryota.
DR   HOGENOM; CLU_008891_3_1_1; -.
DR   InParanoid; Q9M888; -.
DR   OMA; LHPRIMT; -.
DR   OrthoDB; 482152at2759; -.
DR   PhylomeDB; Q9M888; -.
DR   BRENDA; 3.6.4.B10; 399.
DR   PRO; PR:Q9M888; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M888; baseline and differential.
DR   Genevisible; Q9M888; AT.
DR   GO; GO:0005832; C:chaperonin-containing T-complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; HDA:TAIR.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0010043; P:response to zinc ion; IEP:TAIR.
DR   CDD; cd03342; TCP1_zeta; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR012722; Chap_CCT_zeta.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02347; chap_CCT_zeta; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..535
FT                   /note="T-complex protein 1 subunit zeta 1"
FT                   /id="PRO_0000431662"
FT   CONFLICT        17
FT                   /note="A -> T (in Ref. 3; AAK62448)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   535 AA;  58950 MW;  CE624E390DD399E8 CRC64;
     MSVRVLNPNA EVLNKSAALH MTINAAKGLQ DVLKSNLGPK GTIKMLVGGS GDIKLTKDGN
     TLLKEMQIQN PTAIMIARTA VAQDDISGDG TTSTVIFIGE LMKQSERCID EGMHPRVLVD
     GFEIAKRATL QFLDTFKTPV VMGDEPDKEI LKMVARTTLR TKLYEGLADQ LTDIVVNSVL
     CIRKPQEPID LFMVEIMHMR HKFDVDTRLV EGLVLDHGSR HPDMKRRAEN CHILTCNVSL
     EYEKSEINAG FFYSNAEQRE AMVTAERRSV DERVQKIIEL KNKVCAGNDN SFVILNQKGI
     DPPSLDLLAR EGIIALRRAK RRNMERLVLA CGGEAVNSVD DLTPDCLGWA GLVYEHVLGE
     EKYTFVEQVK NPHSCTILIK GPNDHTIAQI KDAVRDGLRS VKNTLEDECV VLGAGAFEVA
     ARQHLINEVK KTVQGRAQLG VEAFANALLV VPKTLAENAG LDTQDVIISL TSEHDKGNIV
     GLDLQDGEPV DPQLAGIFDN YSVKRQLINS GPVIASQLLL VDEVIRAGRN MRKPT