ID   TCPZ_CLAP2              Reviewed;         368 AA.
AC   M1W424;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=C6 finger domain transcription factor tcpZ {ECO:0000303|PubMed:27390873};
DE   AltName: Full=Thioclapurine biosynthesis protein Z {ECO:0000303|PubMed:27390873};
GN   Name=tcpZ {ECO:0000303|PubMed:27390873}; ORFNames=CPUR_02671;
OS   Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX   NCBI_TaxID=1111077;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20.1;
RX   PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA   Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA   Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA   Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA   O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA   Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA   Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA   Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA   Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA   Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA   Yoshida R., Zeng Z.;
RT   "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT   Clavicipitaceae reveals dynamics of alkaloid loci.";
RL   PLoS Genet. 9:E1003323-E1003323(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=27390873; DOI=10.1371/journal.pone.0158945;
RA   Dopstadt J., Neubauer L., Tudzynski P., Humpf H.U.;
RT   "The epipolythiodiketopiperazine gene cluster in Claviceps purpurea:
RT   dysfunctional cytochrome P450 enzyme prevents formation of the previously
RT   unknown clapurines.";
RL   PLoS ONE 11:E0158945-E0158945(2016).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       thioclapurine biosynthesis gene cluster (PubMed:27390873).
CC       {ECO:0000269|PubMed:27390873}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; CAGA01000011; CCE28980.1; -; Genomic_DNA.
DR   AlphaFoldDB; M1W424; -.
DR   SMR; M1W424; -.
DR   STRING; 1111077.M1W424; -.
DR   EnsemblFungi; CCE28980; CCE28980; CPUR_02671.
DR   VEuPathDB; FungiDB:CPUR_02671; -.
DR   eggNOG; ENOG502SSPP; Eukaryota.
DR   HOGENOM; CLU_052542_1_0_1; -.
DR   OrthoDB; 1052137at2759; -.
DR   Proteomes; UP000016801; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..368
FT                   /note="C6 finger domain transcription factor tcpZ"
FT                   /id="PRO_0000437714"
FT   DNA_BIND        30..56
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          84..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40091 MW;  3D4B413D6DAF895A CRC64;
     MNPMLTNNSQ PSNYTAGNAK GKIKKLRSAC DACHASKVRC SGEPICARCQ RDNVACHYSY
     RAHQGKPKGS LNRKTIERMK AAGFIEQRQR PAASQPPGHG TSRDSSVCAS GTTTDNLLNF
     IEIQPPGESN ESPVAIHATP SPCFAMTGGL LPDFDAANLD AFLEAYQTPE DSCLRAVEEF
     PGASPADMDC IFIGTPSSMS RDYTEVATCR CVREITQQIN NVHAASADRS TTGLDDVLHY
     TREISACISG LLQCYSCGGQ VQVFVLASVV LSLLMELMHP LLDSSTDTSR PRAQIRVGNY
     DMSGQLGDVL EKVIVRSIIT KLRQVVDKFE MKADFLRSET AQAEFLKSEA RRLKRGFGRI
     EEGTATLP