TCR5_ECOLX
ID TCR5_ECOLX Reviewed; 405 AA.
AC Q07282;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Tetracycline resistance protein, class E;
DE Short=TetA(E);
GN Name=tetA;
OS Escherichia coli.
OG Plasmid pSL1456.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SLH 1456A;
RX PubMed=8331085; DOI=10.1128/jb.175.14.4554-4560.1993;
RA Allard J.D., Bertrand K.P.;
RT "Sequence of a class E tetracycline resistance gene from Escherichia coli
RT and comparison of related tetracycline efflux proteins.";
RL J. Bacteriol. 175:4554-4560(1993).
CC -!- FUNCTION: Resistance to tetracycline by an active tetracycline efflux.
CC This is an energy-dependent process that decreases the accumulation of
CC the antibiotic in whole cells. This protein functions as a metal-
CC tetracycline/H(+) antiporter.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; L06940; AAA71915.1; -; Unassigned_DNA.
DR PIR; A36896; A36896.
DR RefSeq; WP_063856076.1; NG_048186.1.
DR AlphaFoldDB; Q07282; -.
DR SMR; Q07282; -.
DR TCDB; 2.A.1.2.75; the major facilitator superfamily (mfs).
DR KEGG; ag:AAA71915; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Antiport; Cell inner membrane; Cell membrane;
KW Hydrogen ion transport; Ion transport; Membrane; Plasmid; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..405
FT /note="Tetracycline resistance protein, class E"
FT /id="PRO_0000173396"
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 405 AA; 43413 MW; 991F90467D86BFEB CRC64;
MNRTVMMALV IIFLDAMGIG IIMPVLPALL REFVGKANVA ENYGVLLALY AMMQVIFAPL
LGRWSDRIGR RPVLLLSLLG ATLDYALMAT ASVVWVLYLG RLIAGITGAT GAVAASTIAD
VTPEESRTHW FGMMGACFGG GMIAGPVIGG FAGQLSVQAP FMFAAAINGL AFLVSLFILH
ETHNANQVSD ELKNETINET TSSIREMISP LSGLLVVFFI IQLIGQIPAT LWVLFGEERF
AWDGVMVGVS LAVFGLTHAL FQGLAAGFIA KHLGERKAIA VGILADGCGL FLLAVITQSW
MVWPVLLLLA CGGITLPALQ GIISVRVGQV AQGQLQGVLT SLTHLTAVIG PLVFAFLYSA
TRETWNGWVW IIGCGLYVVA LIILRFFHPG RVIHPINKSD VQQRI
