ID   TCR7_VIBAN              Reviewed;         393 AA.
AC   P51563;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Tetracycline resistance protein, class G;
DE            Short=TetA(G);
GN   Name=tetA;
OS   Vibrio anguillarum (Listonella anguillarum).
OG   Plasmid pJAI22.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MZ8122;
RX   PubMed=1479961; DOI=10.1111/j.1348-0421.1992.tb02109.x;
RA   Zhao J., Aoki T.;
RT   "Nucleotide sequence analysis of the class G tetracycline resistance
RT   determinant from Vibrio anguillarum.";
RL   Microbiol. Immunol. 36:1051-1060(1992).
CC   -!- FUNCTION: Resistance to tetracycline by an active tetracycline efflux.
CC       This is an energy-dependent process that decreases the accumulation of
CC       the antibiotic in whole cells. This protein functions as a metal-
CC       tetracycline/H(+) antiporter.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; S52437; AAB24796.2; -; Genomic_DNA.
DR   RefSeq; WP_032488557.1; NG_048191.1.
DR   AlphaFoldDB; P51563; -.
DR   SMR; P51563; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Antiport; Cell inner membrane; Cell membrane;
KW   Hydrogen ion transport; Ion transport; Membrane; Plasmid; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..393
FT                   /note="Tetracycline resistance protein, class G"
FT                   /id="PRO_0000173397"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  40913 MW;  4175AE56031716F3 CRC64;
     MRSSAIIALL IVGLDAMGLG LIMPVLPTLL RELVPAEQVA GHYGALLSLY ALMQVVFAPM
     LGQLSDSYGR RPVLLASLAG AAVDYTIMAS APVLWVLYIG RLVSGVTGAT GAVAASTIAD
     STGEGSRARW FGYMGACYGA GMIAGPALGG MLGGISAHAP FIAAALLNGF AFLLACIFLK
     ETHHSHGGTG KPVRIKPFVL LRLDDALRGL GALFAVFFII QLIGQVPAAL WVIYGEDRFQ
     WNTATVGLSL AAFGATHAIF QAFVTGPLSS RLGERRTLLF GMAADGTGFV LLAFATQGWM
     VFPILLLLAA GGVGMPALQA MLSNNVSSNK QGALQGTLTS LTNLSSIAGP LGFTALYSAT
     AGAWNGWVWI VGAILYLICL PILRRPFATS LVI