TCR8_PASMD
ID TCR8_PASMD Reviewed; 400 AA.
AC P51564;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Tetracycline resistance protein, class H;
DE Short=TetA(H);
GN Name=tetA;
OS Pasteurella multocida.
OG Plasmid pVM111.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=747;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=P2862;
RX PubMed=8109938; DOI=10.1128/aac.37.12.2699;
RA Hansen L.M., McMurry L.M., Levy S.B., Hirsh D.C.;
RT "A new tetracycline resistance determinant, Tet H, from Pasteurella
RT multocida specifying active efflux of tetracycline.";
RL Antimicrob. Agents Chemother. 37:2699-2705(1993).
CC -!- FUNCTION: Resistance to tetracycline by an active tetracycline efflux.
CC This is an energy-dependent process that decreases the accumulation of
CC the antibiotic in whole cells. This protein functions as a metal-
CC tetracycline/H(+) antiporter.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; U00792; AAC43250.1; -; Unassigned_DNA.
DR RefSeq; WP_032490787.1; NG_048193.1.
DR AlphaFoldDB; P51564; -.
DR SMR; P51564; -.
DR KEGG; ag:AAC43250; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Antiport; Cell inner membrane; Cell membrane;
KW Hydrogen ion transport; Ion transport; Membrane; Plasmid; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..400
FT /note="Tetracycline resistance protein, class H"
FT /id="PRO_0000173398"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 400 AA; 43672 MW; 01F9EBEF3E26BB5D CRC64;
MNKSIIIILL ITVLDAIGIG LIMPVLPTLL NEFVSENSLA THYGVLLALY ATMQVIFAPI
LGRLSDKYGR KPILLFSLLG AALDYLLMAF STTLWMLYIG RIIAGITGAT GAVCASAMSD
VTPAKNRTRY FGFLGGVFGV GLIIGPMLGG LLGDISAHMP FIFAAISHSI LLILSLLFFR
ETQKREALVA NRTPENQTAS NTVTVFFKKS LYFWLATYFI IQLIGQIPAT IWVLFTQYRF
DWNTTSIGMS LAVLGVLHIF FQAIVAGKLA QKWGEKTTIM ISMSIDMMGC LLLAWIGHVW
VILPALICLA AGGMGQPALQ GYLSKSVDDN AQGKLQGTLV SLTNITGIIG PLLFAFIYSY
SVAYWDGLLW LMGAILYAML LITAYFHQRK TTPKAVISTP
