ID   TCRA2_MYCTO             Reviewed;         253 AA.
AC   Q7D9K0;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Transcriptional regulatory protein TcrA;
GN   Name=tcrA; OrderedLocusNames=MT0631;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Member of the two-component system HK/TcrA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by HK. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK44855.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_003403148.1; NZ_KK341227.1.
DR   AlphaFoldDB; Q7D9K0; -.
DR   SMR; Q7D9K0; -.
DR   EnsemblBacteria; AAK44855; AAK44855; MT0631.
DR   KEGG; mtc:MT0631; -.
DR   PATRIC; fig|83331.31.peg.665; -.
DR   HOGENOM; CLU_000445_30_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..253
FT                   /note="Transcriptional regulatory protein TcrA"
FT                   /id="PRO_0000391083"
FT   DOMAIN          24..138
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        146..244
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         73
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   253 AA;  28170 MW;  E4F0DA2EA8E1BA18 CRC64;
     MADETTMRAG RGPGRACGRV SGVRILVVED EPKMTALLAR ALTEEGHTVD TVADGRHAVA
     AVDGGDYDAV VLDVMLPGID GFEVCARLRR QRVWTPVLML TARGAVTDRI AGLDGGADDY
     LTKPFNLDEL FARLRALSRR GPIPRPPTLE AGDLRLDPSE HRVWRADTEI RLSHKEFTLL
     EALIRRPGIV HTRAQLLERC WDAAYEARSN IVDVYIRYLR DKIDRPFGVT SLETIRGAGY
     RLRKDGGRHA LPR