TCRGL_HUMAN
ID TCRGL_HUMAN Reviewed; 586 AA.
AC Q5VWI1; Q5VWI2; Q86XM8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Transcription elongation regulator 1-like protein;
GN Name=TCERG1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-339; LYS-529 AND
RP LYS-566.
RC TISSUE=Brain cortex, and Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT [LARGE SCALE ANALYSIS] THR-437.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH42951.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH93639.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI01536.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC067746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042951; AAH42951.1; ALT_INIT; mRNA.
DR EMBL; BC093639; AAH93639.1; ALT_INIT; mRNA.
DR EMBL; BC101535; AAI01536.1; ALT_INIT; mRNA.
DR CCDS; CCDS7662.2; -.
DR RefSeq; NP_777597.2; NM_174937.3.
DR AlphaFoldDB; Q5VWI1; -.
DR SMR; Q5VWI1; -.
DR BioGRID; 129171; 1.
DR STRING; 9606.ENSP00000357631; -.
DR iPTMnet; Q5VWI1; -.
DR PhosphoSitePlus; Q5VWI1; -.
DR BioMuta; TCERG1L; -.
DR DMDM; 172045963; -.
DR EPD; Q5VWI1; -.
DR jPOST; Q5VWI1; -.
DR MassIVE; Q5VWI1; -.
DR MaxQB; Q5VWI1; -.
DR PaxDb; Q5VWI1; -.
DR PeptideAtlas; Q5VWI1; -.
DR PRIDE; Q5VWI1; -.
DR ProteomicsDB; 65529; -.
DR Antibodypedia; 32526; 77 antibodies from 16 providers.
DR DNASU; 256536; -.
DR Ensembl; ENST00000368642.4; ENSP00000357631.4; ENSG00000176769.9.
DR GeneID; 256536; -.
DR KEGG; hsa:256536; -.
DR MANE-Select; ENST00000368642.4; ENSP00000357631.4; NM_174937.4; NP_777597.2.
DR UCSC; uc001lkp.4; human.
DR CTD; 256536; -.
DR DisGeNET; 256536; -.
DR GeneCards; TCERG1L; -.
DR HGNC; HGNC:23533; TCERG1L.
DR HPA; ENSG00000176769; Tissue enhanced (brain, retina, thyroid gland).
DR neXtProt; NX_Q5VWI1; -.
DR OpenTargets; ENSG00000176769; -.
DR PharmGKB; PA134864258; -.
DR VEuPathDB; HostDB:ENSG00000176769; -.
DR eggNOG; KOG0155; Eukaryota.
DR GeneTree; ENSGT00940000160593; -.
DR HOGENOM; CLU_039298_0_0_1; -.
DR InParanoid; Q5VWI1; -.
DR OMA; HVCPSAL; -.
DR OrthoDB; 1388955at2759; -.
DR PhylomeDB; Q5VWI1; -.
DR TreeFam; TF317748; -.
DR PathwayCommons; Q5VWI1; -.
DR BioGRID-ORCS; 256536; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; TCERG1L; human.
DR GenomeRNAi; 256536; -.
DR Pharos; Q5VWI1; Tbio.
DR PRO; PR:Q5VWI1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5VWI1; protein.
DR Bgee; ENSG00000176769; Expressed in right lobe of thyroid gland and 75 other tissues.
DR Genevisible; Q5VWI1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070063; F:RNA polymerase binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.10.10.440; -; 2.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR045148; TCRG1-like.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR15377; PTHR15377; 1.
DR Pfam; PF01846; FF; 2.
DR SMART; SM00441; FF; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR SUPFAM; SSF81698; SSF81698; 2.
DR PROSITE; PS51676; FF; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..586
FT /note="Transcription elongation regulator 1-like protein"
FT /id="PRO_0000312872"
FT DOMAIN 148..181
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 339..372
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 450..503
FT /note="FF 1"
FT DOMAIN 515..570
FT /note="FF 2"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 339
FT /note="P -> Q (in dbSNP:rs17857275)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037601"
FT VARIANT 437
FT /note="K -> T (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1480561756)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_037602"
FT VARIANT 529
FT /note="E -> K (in dbSNP:rs17857276)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037603"
FT VARIANT 566
FT /note="Q -> K (in dbSNP:rs17854242)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037604"
FT CONFLICT 23
FT /note="Q -> R (in Ref. 2; AAH93639)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 586 AA; 65660 MW; 473F0274B5C8BE5A CRC64;
MQAGARFQRR RRQLQQQQPR RRQPLLWPMD AEPPPPPPWV WMVPGSAGLL RLSAGVVVPP
VLLASAPPPA APLLPGLPGW PAPSEPVLPL LPLPSAPDSA AAAAAHPFPA LHGQWLFGGH
SPSLGLPPSS TVELVPVFPH LCPSALATPI GKSWIDKRIP NCKIFFNNSF ALDSTWIHPE
ESRFFHGHEK PRLLANQVAV SLSRPAPASR PLPTVVLAPQ PIPGGCHNSL KVTSSPAIAI
ATAAAAAMVS VDPENLRGPS PSSVQPRHFL TLAPIKIPLR TSPVSDTRTE RGRVARPPAL
MLRAQKSRDG DKEDKEPPPM LGGGEDSTAR GNRPVASTPV PGSPWCVVWT GDDRVFFFNP
TMHLSVWEKP MDLKDRGDLN RIIEDPPHKR KLEAPATDNS DGSSSEDNRE DQDVKTKRNR
TEGCGSPKPE EAKREDKGTR TPPPQILLPL EERVTHFRDM LLERGVSAFS TWEKELHKIV
FDPRYLLLNS EERKQIFEQF VKTRIKEEYK EKKSKLLLAK EEFKKLLEES KVSPRTTFKE
FAEKYGRDQR FRLVQKRKDQ EHFFNQFILI LKKRDKENRL RLRKMR
