TCRGL_MOUSE
ID TCRGL_MOUSE Reviewed; 590 AA.
AC Q3B807; Q80ZP6; Q8BT57;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transcription elongation regulator 1-like protein;
GN Name=Tcerg1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-590 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-581 (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3B807-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3B807-2; Sequence=VSP_029926, VSP_029927;
CC Name=3;
CC IsoId=Q3B807-3; Sequence=VSP_029925;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48631.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAI07235.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI07236.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC25528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC25528.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC127598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC127287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK017700; BAC25528.1; ALT_SEQ; mRNA.
DR EMBL; BC048631; AAH48631.1; ALT_SEQ; mRNA.
DR EMBL; BC107234; AAI07235.1; ALT_INIT; mRNA.
DR EMBL; BC107235; AAI07236.1; ALT_INIT; mRNA.
DR CCDS; CCDS40167.2; -. [Q3B807-1]
DR RefSeq; NP_899112.2; NM_183289.3. [Q3B807-1]
DR AlphaFoldDB; Q3B807; -.
DR SMR; Q3B807; -.
DR STRING; 10090.ENSMUSP00000124476; -.
DR iPTMnet; Q3B807; -.
DR PhosphoSitePlus; Q3B807; -.
DR MaxQB; Q3B807; -.
DR PaxDb; Q3B807; -.
DR PeptideAtlas; Q3B807; -.
DR PRIDE; Q3B807; -.
DR Antibodypedia; 32526; 77 antibodies from 16 providers.
DR DNASU; 70571; -.
DR Ensembl; ENSMUST00000160436; ENSMUSP00000124476; ENSMUSG00000091002. [Q3B807-1]
DR GeneID; 70571; -.
DR KEGG; mmu:70571; -.
DR UCSC; uc009kez.1; mouse. [Q3B807-2]
DR UCSC; uc012fvn.1; mouse. [Q3B807-1]
DR CTD; 256536; -.
DR MGI; MGI:1917821; Tcerg1l.
DR VEuPathDB; HostDB:ENSMUSG00000091002; -.
DR eggNOG; KOG0155; Eukaryota.
DR GeneTree; ENSGT00940000160593; -.
DR HOGENOM; CLU_039298_0_0_1; -.
DR InParanoid; Q3B807; -.
DR OMA; HVCPSAL; -.
DR OrthoDB; 1388955at2759; -.
DR PhylomeDB; Q3B807; -.
DR TreeFam; TF317748; -.
DR BioGRID-ORCS; 70571; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tcerg1l; mouse.
DR PRO; PR:Q3B807; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3B807; protein.
DR Bgee; ENSMUSG00000091002; Expressed in lateral septal nucleus and 120 other tissues.
DR Genevisible; Q3B807; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070063; F:RNA polymerase binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.10.10.440; -; 2.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR045148; TCRG1-like.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR15377; PTHR15377; 1.
DR Pfam; PF01846; FF; 2.
DR SMART; SM00441; FF; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; SSF51045; 1.
DR SUPFAM; SSF81698; SSF81698; 2.
DR PROSITE; PS51676; FF; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..590
FT /note="Transcription elongation regulator 1-like protein"
FT /id="PRO_0000312873"
FT DOMAIN 145..178
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 343..376
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 454..507
FT /note="FF 1"
FT DOMAIN 519..574
FT /note="FF 2"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..365
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029925"
FT VAR_SEQ 401..402
FT /note="TE -> SN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029926"
FT VAR_SEQ 403..590
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029927"
FT CONFLICT 294
FT /note="S -> R (in Ref. 1; BAC25528)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="P -> S (in Ref. 1; BAC25528)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="K -> N (in Ref. 1; BAC25528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 590 AA; 66376 MW; AB869DB42F835F91 CRC64;
MLAGARLQRR RRQLQQPQQP RWRQPLPWPM NADPPPPPWV WMVPGTAGLL RLGAGVAPPP
VLLASAQPAS APLLPRLPGW PAPGEPLLPL LPLSSAPDHA AVHHYPLLHG QWLFGGHSPS
IGLAPSSAVE LVPLFPHVCP STLSPPVGKN WIDKRMPNYK IFFNNPFALD STWMYPEESV
LFHSHEKTHF LANQVTPSLS RPTPASRPLP TVVLAAQPIP GGCHDSLKPI SRGPTITITA
ATAAAAATAM VSVDPEELRG LSPSIMQPCH FLTLTPIRIP FRTAPFSDKG KEHSRAPRSP
ALMLRAPERK SLVGDKEDKE PPPILVRGEE TAAKGNKPVA STPVPGSPWC VVWTGDDRVF
FFNPTMQLSV WEKPVDLQNR GDLKRIIEDP PHKRKLEASA TESSDGSSSD DGSEDQSVKT
KRNRTESCEG PGPEDTHQVD KGPQTPPPQI LLPLEERVTH FRDMLLERGV SAFSTWEKEL
HKIVFDPRYL LLNSEERKQI FEQFVKTRIK EEYKERKSKL LLAKEEFKKL LEESKVSPRT
TFKEFAEKHG RDQRFRLVQK RKDQEHFFNQ FILILKKRDK ENRLRLRKMR
