ID   TCR_STAES               Reviewed;         459 AA.
AC   P62967; P14512;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Tetracycline resistance protein;
GN   Name=tet; OrderedLocusNames=SE_p101;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OG   Plasmid pSE-12228-01.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Resistance to tetracycline by an active tetracycline efflux.
CC       This is an energy-dependent process that decreases the accumulation of
CC       the antibiotic in whole cells. This protein functions as a metal-
CC       tetracycline/H(+) antiporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015930; AAO06148.1; -; Genomic_DNA.
DR   RefSeq; NP_863256.1; NC_005008.1.
DR   RefSeq; WP_000492283.1; NZ_WBME01000087.1.
DR   AlphaFoldDB; P62967; -.
DR   SMR; P62967; -.
DR   EnsemblBacteria; AAO06148; AAO06148; SE_p101.
DR   GeneID; 50019748; -.
DR   GeneID; 61682012; -.
DR   GeneID; 64117985; -.
DR   KEGG; sep:SE_p101; -.
DR   PATRIC; fig|176280.10.peg.2431; -.
DR   HOGENOM; CLU_000960_3_0_9; -.
DR   OMA; ESRAMNH; -.
DR   Proteomes; UP000001411; Plasmid pSE-12228-01.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Antiport; Cell membrane; Hydrogen ion transport;
KW   Ion transport; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..459
FT                   /note="Tetracycline resistance protein"
FT                   /id="PRO_0000173385"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  50695 MW;  FE53C55535372B41 CRC64;
     MFSLYKKFKG LFYSVLFWLC ILSFFSVLNE MVLNVSLPDI ANHFNTTPGI TNWVNTAYML
     TFSIGTAVYG KLSDYINIKK LLIIGISLSC LGSLIAFIGH NHFFILIFGR LVQGVGSAAF
     PSLIMVVVAR NITRKKQGKA FGFIGSIVAL GEGLGPSIGG IIAHYIHWSY LLILPMITIV
     TIPFLIKVMV PGKSTKNTLD IVGIVLMSIS IICFMLFTTN YNWTFLILFT IFFVIFIKHI
     SRVSNPFINP KLGKNIPFML GLFSGGLIFS IVAGFISMVP YMMKTIYHVN VATIGNSVIF
     PGTMSVIVFG YFGGFLVDRK GSLFVFILGS LSISISFLTI AFFVEFSMWL TTFMFIFVMG
     GLSFTKTVIS KIVSSSLSEE EVASGMSLLN FTSFLSEGTG IAIVGGLLSL QLINRKLVLE
     FINYSSGVYS NILVAMAILI ILCCLLTIIV FKRSEKQFE