TCR_STAHY
ID TCR_STAHY Reviewed; 458 AA.
AC P36890;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Tetracycline resistance protein;
GN Name=tet;
OS Staphylococcus hyicus.
OG Plasmid pSTE1.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1284;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1622166; DOI=10.1128/aac.36.3.580;
RA Schwarz S., Cardoso M., Wegener H.C.;
RT "Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance
RT determinant encoded by plasmid pSTE1 from Staphylococcus hyicus.";
RL Antimicrob. Agents Chemother. 36:580-588(1992).
CC -!- FUNCTION: Resistance to tetracycline by an active tetracycline efflux.
CC This is an energy-dependent process that decreases the accumulation of
CC the antibiotic in whole cells. This protein functions as a metal-
CC tetracycline/H(+) antiporter.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; X60828; CAA43220.1; -; Genomic_DNA.
DR PIR; S23743; S23743.
DR RefSeq; WP_032488409.1; NG_048205.1.
DR AlphaFoldDB; P36890; -.
DR SMR; P36890; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Antiport; Cell membrane; Hydrogen ion transport;
KW Ion transport; Membrane; Plasmid; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..458
FT /note="Tetracycline resistance protein"
FT /id="PRO_0000173387"
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..451
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 458 AA; 49954 MW; 418425D735B9BF8D CRC64;
MNTSYSQSNL RHNQILIWLC ILSFFSVLNE MVLNVSLPDI ANDFNKPPAS TNWVNTAFML
TFSIGTAVYG KLSDQLGIKR LLLFGIIINC FGSVIGFVGH SFFSLLIMAR FIQGAGAAAF
PALVMVVVAR YIPKENRGKA FGLIGSIVAM GEGVGPAIGG MIAHYIHWSY LLLIPIITII
TVPFLMKLLK KEVRIKGHFG SKGIILMSVG IVFFMLFTTS YSISFLIVSV LSFLIFVKHI
RKVTDPFVDP GLGKNIPFMI GVLCGGIIFG TVAGFVSMVP YMMKDVHQLS TAEIGSVIIF
PGTMSVIIFG YIGGILVDRR VPLYALNIGV TFLSVSFLTA SFLLETTSWF MTIIIVFVLG
GLSFTKTVIS TIVSSSLKQQ EAGAGMSLLN FTSLLSEGTG IAIVGGLLSI PLLDPRLLPM
EVDQSTYLYS NLLLLFSGII VISWLVTLNL YKHSQRDF
