ID   TCSA_LISMO              Reviewed;         357 AA.
AC   Q48754;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=CD4+ T-cell-stimulating antigen;
DE   Flags: Precursor;
GN   Name=tcsA; OrderedLocusNames=lmo1388;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-252.
RC   STRAIN=85EO-1167;
RX   PubMed=7500019; DOI=10.1084/jem.182.6.1751;
RA   Sanderson S., Campbell D.J., Shastri N.;
RT   "Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria
RT   by expression cloning.";
RL   J. Exp. Med. 182:1751-1757(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BMP lipoprotein family. {ECO:0000305}.
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DR   EMBL; AL591979; CAC99466.1; -; Genomic_DNA.
DR   EMBL; S80336; AAB35725.2; ALT_TERM; Genomic_DNA.
DR   PIR; AD1248; AD1248.
DR   RefSeq; NP_464913.1; NC_003210.1.
DR   RefSeq; WP_003722514.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q48754; -.
DR   SMR; Q48754; -.
DR   STRING; 169963.lmo1388; -.
DR   PaxDb; Q48754; -.
DR   PRIDE; Q48754; -.
DR   EnsemblBacteria; CAC99466; CAC99466; CAC99466.
DR   GeneID; 984815; -.
DR   KEGG; lmo:lmo1388; -.
DR   PATRIC; fig|169963.11.peg.1426; -.
DR   eggNOG; COG1744; Bacteria.
DR   HOGENOM; CLU_038813_0_0_9; -.
DR   OMA; LASMMKR; -.
DR   PhylomeDB; Q48754; -.
DR   BioCyc; LMON169963:LMO1388-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR003760; PnrA-like.
DR   Pfam; PF02608; Bmp; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000305"
FT   CHAIN           23..357
FT                   /note="CD4+ T-cell-stimulating antigen"
FT                   /id="PRO_0000018006"
FT   LIPID           23
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           23
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   357 AA;  38415 MW;  83605B8B6419C8D1 CRC64;
     MKKRTFALAL SMIIASGVIL GACGSSSDDK KSSDDKSSKD FTVAMVTDTG GVDDRSFNQS
     AWEGLQKFGK ANDMEKGTDG YNYLQSASEA DYKTNLNTAV RSDYDLIYGI GYKLKDAIEE
     VSKQKPKNQF AIVDDTIDDR DNVVSIGFKD NDGSYLVGVV AGLTTKTNKV GFVGGVKGTV
     IDRFEAGFTA GVKAVNPNAQ IDVQYANDFA KADKGQQIAS SMYSSGVDVI FHAAGGTGNG
     VFAEAKNLKK KDPSRAVWVI GVDRDQWDEG KVTANDGKDY NVTLTSEIKR VDIAVEDLAT
     RAKAGDFPGG TKIEYGLDKD AVGLSEHQDN ISKDVLAKVE EYKQKIVDGD IKVPEKP