ID   TCSR2_PAESO             Reviewed;         173 AA.
AC   P0DUB5;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=RNA polymerase sigma factor TcsR {ECO:0000305};
GN   Name=tcsR {ECO:0000303|PubMed:23873908};
OS   Paeniclostridium sordellii (Clostridium sordellii).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Paeniclostridium.
OX   NCBI_TaxID=1505;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VPI 9048 {ECO:0000312|EMBL:AHB59890.1};
RA   Popoff M.-R., Pauillac S., Bouvet P., Just I., Genth H., Bouchier C.;
RT   "Clostridium sordellii variant toxins TcsL9048 and TcsH9048, gene
RT   characterization and comparative analysis of substrate specificity of the
RT   large clostridial glucosylating toxins.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RC   STRAIN=VPI 9048;
RX   PubMed=23873908; DOI=10.1128/jb.00711-13;
RA   Sirigi Reddy A.R., Girinathan B.P., Zapotocny R., Govind R.;
RT   "Identification and characterization of Clostridium sordellii toxin gene
RT   regulator.";
RL   J. Bacteriol. 195:4246-4254(2013).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released (Probable). Transcriptional regulator specifically required to
CC       activate expression of the toxin gene locus, composed of tcsL, tcsH and
CC       tcdE/utxA (PubMed:23873908). {ECO:0000269|PubMed:23873908,
CC       ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; KF726113; AHB59890.1; -; Genomic_DNA.
DR   RefSeq; WP_021127582.1; NZ_MG205642.1.
DR   AlphaFoldDB; P0DUB5; -.
DR   SMR; P0DUB5; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   SUPFAM; SSF88659; SSF88659; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..173
FT                   /note="RNA polymerase sigma factor TcsR"
FT                   /id="PRO_0000451204"
FT   DNA_BIND        143..162
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000305"
FT   REGION          122..169
FT                   /note="Sigma-70 factor domain-4"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  20736 MW;  47864DF29123BD43 CRC64;
     MSNLYESIRK YKCGYIEEIL NILDMFDPLL NKFQRNSCYE DMKSELSLFM FNLIDNFPLE
     KDCFKEDKFI INYIYKALKN KFIQVNKLHQ KIKSCESNID IVALNNCDYS NLLSFVIFED
     IIKDLTQNEK NIIRKIYLDR LRESEISREL NISRQAVNKT HLRALEKLKK LIN