ID   TCT2_PHYPO              Reviewed;         353 AA.
AC   O61064;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Tectonin-2;
DE   AltName: Full=Tectonin II;
GN   Name=TECB;
OS   Physarum polycephalum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC   Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX   NCBI_TaxID=5791;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   STRAIN=M3;
RX   PubMed=9497393; DOI=10.1074/jbc.273.11.6565;
RA   Huh C.-G., Aldrich J., Mottahedeh J., Kwon H., Johnson C., Marsh R.;
RT   "Cloning and characterization of Physarum polycephalum tectonins.
RT   Homologues of Limulus lectin L-6.";
RL   J. Biol. Chem. 273:6565-6574(1998).
CC   -!- FUNCTION: Probably involved in bacterial recognition. May be a lectin
CC       that function as part of a transmembrane signaling complex during
CC       phagocytosis.
CC   -!- SUBCELLULAR LOCATION: Cell surface. Cytoplasmic vesicle membrane.
CC       Note=Also bound to inner membrane of certain cytoplasmic vesicles.
CC   -!- SIMILARITY: Belongs to the tectonin family. {ECO:0000305}.
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DR   EMBL; AF041456; AAC06201.1; -; mRNA.
DR   AlphaFoldDB; O61064; -.
DR   SMR; O61064; -.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0043157; P:response to cation stress; IEA:UniProt.
DR   InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF19193; Tectonin; 1.
DR   SMART; SM00706; TECPR; 6.
DR   SUPFAM; SSF50370; SSF50370; 1.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Lectin; Membrane; Repeat.
FT   CHAIN           1..353
FT                   /note="Tectonin-2"
FT                   /id="PRO_0000221477"
FT   DOMAIN          44..93
FT                   /note="Ricin B-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REPEAT          138..173
FT                   /note="1"
FT   REPEAT          174..210
FT                   /note="2"
FT   REPEAT          211..247
FT                   /note="3"
FT   REPEAT          248..282
FT                   /note="4"
FT   REPEAT          283..318
FT                   /note="5"
FT   REPEAT          319..353
FT                   /note="6"
FT   REGION          138..353
FT                   /note="6 X approximate tandem repeats"
SQ   SEQUENCE   353 AA;  39268 MW;  C5691932C66C9E09 CRC64;
     MATPVYIVLP SRPDHVVSTA KDHAVQGYTE LHPYDPSQTE GRLWIFDNDG YIRLAANHNL
     VLDVNGGAAK EGNTVLSYPD KKDHAKNQLW VNKDCILHTK LDESFHLGVN DKGQVIITQK
     KEQRVILRAP ASLEKRPSAW ERHEGELNVV AVGAGNHDVW GVNHLEHIYH WDGSKWHQIE
     GAATNISVGL DGTVWCVNKA HEIYRLDRGT NKWSIVPGEL VQVSVGNSHN IWGVNHLDAI
     YKWNADSNSW TFVDGQLTNV SVGHDGTVYG VNRAGNIYHY NGNSWDAVSG ELVQIHVANK
     DLIVGVNKAG HVYRLKHGKD WEKLEGELSW VAVGHGGELW GANSAHNIYK ALL