TCTA_BOVIN
ID TCTA_BOVIN Reviewed; 106 AA.
AC Q5EAA5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=T-cell leukemia translocation-altered gene protein homolog;
GN Name=TCTA;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be required for cellular fusion during
CC osteoclastogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TCTA family. {ECO:0000305}.
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DR EMBL; BC103014; AAI03015.1; -; mRNA.
DR EMBL; BT020664; AAX08681.1; -; mRNA.
DR RefSeq; NP_001029961.1; NM_001034789.2.
DR AlphaFoldDB; Q5EAA5; -.
DR STRING; 9913.ENSBTAP00000030636; -.
DR PaxDb; Q5EAA5; -.
DR Ensembl; ENSBTAT00000030664; ENSBTAP00000030636; ENSBTAG00000022632.
DR GeneID; 616169; -.
DR KEGG; bta:616169; -.
DR CTD; 6988; -.
DR VEuPathDB; HostDB:ENSBTAG00000022632; -.
DR eggNOG; ENOG502S6IC; Eukaryota.
DR GeneTree; ENSGT00390000004490; -.
DR HOGENOM; CLU_157357_0_0_1; -.
DR InParanoid; Q5EAA5; -.
DR OMA; ESIKTHR; -.
DR OrthoDB; 1490819at2759; -.
DR TreeFam; TF330748; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000022632; Expressed in corpus epididymis and 105 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0072675; P:osteoclast fusion; IBA:GO_Central.
DR InterPro; IPR016560; TCTA.
DR PANTHER; PTHR32267; PTHR32267; 1.
DR Pfam; PF15128; T_cell_tran_alt; 1.
DR PIRSF; PIRSF009935; TCTA; 1.
PE 3: Inferred from homology;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P57738"
FT CHAIN 2..106
FT /note="T-cell leukemia translocation-altered gene protein
FT homolog"
FT /id="PRO_0000301678"
FT TOPO_DOM 2..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 74..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P57738"
SQ SEQUENCE 106 AA; 11615 MW; 99EA01ED6AE04AD8 CRC64;
MAEPWSGQSL QALPATVLGA LGALGSEFLR EWEAQDMRVT LFKLLLFWLV LSLLSIQLAW
GFYGSTVTGL YHRPGLGGQN GSTPDGSTHF PSWETAANEP LKTHRE
