TCTA_HUMAN
ID TCTA_HUMAN Reviewed; 103 AA.
AC P57738; B2R4I4; Q6I9U4; Q9BSB0;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=T-cell leukemia translocation-altered gene protein;
DE AltName: Full=T-cell leukemia translocation-associated gene protein;
GN Name=TCTA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=7728759;
RA Aplan P.D., Johnson B.E., Russell E., Chervinsky D.S., Kirsch I.R.;
RT "Cloning and characterization of TCTA, a gene located at the site of a
RT t(1;3) translocation.";
RL Cancer Res. 55:1917-1921(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION.
RX PubMed=19560569; DOI=10.1016/j.bone.2009.06.019;
RA Kotake S., Nanke Y., Kawamoto M., Yago T., Udagawa N., Ichikawa N.,
RA Kobashigawa T., Saito S., Momohara S., Kamatani N., Yamanaka H.;
RT "T-cell leukemia translocation-associated gene (TCTA) protein is required
RT for human osteoclastogenesis.";
RL Bone 45:627-639(2009).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May be required for cellular fusion during
CC osteoclastogenesis. {ECO:0000269|PubMed:19560569}.
CC -!- INTERACTION:
CC P57738; O95393: BMP10; NbExp=3; IntAct=EBI-6447595, EBI-3922513;
CC P57738; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-6447595, EBI-2807956;
CC P57738; P78382: SLC35A1; NbExp=3; IntAct=EBI-6447595, EBI-12870360;
CC P57738; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-6447595, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest level of expression in kidney.
CC Present in monocytes, osteoclasts, macrophages, synoviocytes and
CC synovial lining cells (at protein level). {ECO:0000269|PubMed:7728759}.
CC -!- DISEASE: Note=A chromosomal aberration involving TCTA is associated
CC with T-cell acute lymphoblastic leukemia (T-ALL). Translocation
CC t(1;3)(p34;p21).
CC -!- SIMILARITY: Belongs to the TCTA family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TCTAID58.html";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L41143; AAA97514.1; -; mRNA.
DR EMBL; AK311839; BAG34781.1; -; mRNA.
DR EMBL; CR457411; CAG33692.1; -; mRNA.
DR EMBL; AC104452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005157; AAH05157.2; -; mRNA.
DR CCDS; CCDS2796.1; -.
DR PIR; I52722; I52722.
DR RefSeq; NP_071503.1; NM_022171.2.
DR AlphaFoldDB; P57738; -.
DR BioGRID; 112848; 7.
DR IntAct; P57738; 7.
DR MINT; P57738; -.
DR STRING; 9606.ENSP00000273590; -.
DR GlyGen; P57738; 1 site.
DR iPTMnet; P57738; -.
DR PhosphoSitePlus; P57738; -.
DR BioMuta; TCTA; -.
DR MassIVE; P57738; -.
DR MaxQB; P57738; -.
DR PaxDb; P57738; -.
DR PeptideAtlas; P57738; -.
DR PRIDE; P57738; -.
DR ProteomicsDB; 57026; -.
DR TopDownProteomics; P57738; -.
DR Antibodypedia; 1537; 69 antibodies from 21 providers.
DR DNASU; 6988; -.
DR Ensembl; ENST00000273590.4; ENSP00000273590.3; ENSG00000145022.5.
DR GeneID; 6988; -.
DR KEGG; hsa:6988; -.
DR MANE-Select; ENST00000273590.4; ENSP00000273590.3; NM_022171.3; NP_071503.1.
DR UCSC; uc003cwv.5; human.
DR CTD; 6988; -.
DR DisGeNET; 6988; -.
DR GeneCards; TCTA; -.
DR HGNC; HGNC:11692; TCTA.
DR HPA; ENSG00000145022; Low tissue specificity.
DR MIM; 600690; gene.
DR neXtProt; NX_P57738; -.
DR OpenTargets; ENSG00000145022; -.
DR PharmGKB; PA36412; -.
DR VEuPathDB; HostDB:ENSG00000145022; -.
DR eggNOG; ENOG502S6IC; Eukaryota.
DR GeneTree; ENSGT00390000004490; -.
DR HOGENOM; CLU_157357_0_0_1; -.
DR InParanoid; P57738; -.
DR OMA; ESIKTHR; -.
DR OrthoDB; 1490819at2759; -.
DR PhylomeDB; P57738; -.
DR TreeFam; TF330748; -.
DR PathwayCommons; P57738; -.
DR SignaLink; P57738; -.
DR BioGRID-ORCS; 6988; 7 hits in 1076 CRISPR screens.
DR ChiTaRS; TCTA; human.
DR GenomeRNAi; 6988; -.
DR Pharos; P57738; Tbio.
DR PRO; PR:P57738; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P57738; protein.
DR Bgee; ENSG00000145022; Expressed in right adrenal gland and 196 other tissues.
DR Genevisible; P57738; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IDA:UniProtKB.
DR GO; GO:0072675; P:osteoclast fusion; IDA:UniProtKB.
DR InterPro; IPR016560; TCTA.
DR PANTHER; PTHR32267; PTHR32267; 1.
DR Pfam; PF15128; T_cell_tran_alt; 1.
DR PIRSF; PIRSF009935; TCTA; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chromosomal rearrangement; Glycoprotein; Membrane;
KW Proto-oncogene; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CHAIN 2..103
FT /note="T-cell leukemia translocation-altered gene protein"
FT /id="PRO_0000072470"
FT TOPO_DOM 2..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 71..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 103
FT /note="E -> D (in Ref. 3; CAG33692)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 103 AA; 11341 MW; 62FA7ECC2241D85E CRC64;
MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY
GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE
