TCTA_MOUSE
ID TCTA_MOUSE Reviewed; 122 AA.
AC Q8VEA7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=T-cell leukemia translocation-altered gene protein homolog;
GN Name=Tcta;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=19560569; DOI=10.1016/j.bone.2009.06.019;
RA Kotake S., Nanke Y., Kawamoto M., Yago T., Udagawa N., Ichikawa N.,
RA Kobashigawa T., Saito S., Momohara S., Kamatani N., Yamanaka H.;
RT "T-cell leukemia translocation-associated gene (TCTA) protein is required
RT for human osteoclastogenesis.";
RL Bone 45:627-639(2009).
CC -!- FUNCTION: May be required for cellular fusion during
CC osteoclastogenesis. {ECO:0000250, ECO:0000269|PubMed:19560569}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TCTA family. {ECO:0000305}.
CC -!- CAUTION: Although demonstrated for the human ortholog, involvement in
CC osteoclastogenesis failed to be demonstrated in mouse cells.
CC {ECO:0000305}.
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DR EMBL; AK133663; BAE21771.1; -; mRNA.
DR EMBL; BC019397; AAH19397.1; -; mRNA.
DR CCDS; CCDS23520.1; -.
DR RefSeq; NP_598747.1; NM_133986.2.
DR AlphaFoldDB; Q8VEA7; -.
DR STRING; 10090.ENSMUSP00000045063; -.
DR GlyGen; Q8VEA7; 1 site.
DR iPTMnet; Q8VEA7; -.
DR PhosphoSitePlus; Q8VEA7; -.
DR PaxDb; Q8VEA7; -.
DR PRIDE; Q8VEA7; -.
DR Antibodypedia; 1537; 69 antibodies from 21 providers.
DR DNASU; 102791; -.
DR Ensembl; ENSMUST00000044725; ENSMUSP00000045063; ENSMUSG00000039461.
DR GeneID; 102791; -.
DR KEGG; mmu:102791; -.
DR UCSC; uc009rpd.1; mouse.
DR CTD; 6988; -.
DR MGI; MGI:1918829; Tcta.
DR VEuPathDB; HostDB:ENSMUSG00000039461; -.
DR eggNOG; ENOG502S6IC; Eukaryota.
DR GeneTree; ENSGT00390000004490; -.
DR InParanoid; Q8VEA7; -.
DR OrthoDB; 1490819at2759; -.
DR PhylomeDB; Q8VEA7; -.
DR TreeFam; TF330748; -.
DR BioGRID-ORCS; 102791; 2 hits in 60 CRISPR screens.
DR ChiTaRS; Tcta; mouse.
DR PRO; PR:Q8VEA7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VEA7; protein.
DR Bgee; ENSMUSG00000039461; Expressed in motor neuron and 264 other tissues.
DR ExpressionAtlas; Q8VEA7; baseline and differential.
DR Genevisible; Q8VEA7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:MGI.
DR GO; GO:0072675; P:osteoclast fusion; ISO:MGI.
DR InterPro; IPR016560; TCTA.
DR PANTHER; PTHR32267; PTHR32267; 1.
DR Pfam; PF15128; T_cell_tran_alt; 1.
DR PIRSF; PIRSF009935; TCTA; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P57738"
FT CHAIN 2..122
FT /note="T-cell leukemia translocation-altered gene protein
FT homolog"
FT /id="PRO_0000301679"
FT TOPO_DOM 2..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..122
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 82..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P57738"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 122 AA; 13297 MW; D476FE09F34809ED CRC64;
MAEPWAGQFL QALPATVLGA LGTLGSDFLR EWETQDMRVT LFKLLLLWLV LSLLGIQLAW
GFYGNTVTGL YHRPDPHPQP PAAMGVFLPP GLGGQNGSTP DGSTHFSSWE IAANEALKTH
RE
