ID   TCTD_SALTY              Reviewed;         224 AA.
AC   P0CL17; P22104;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Transcriptional regulatory protein TctD;
GN   Name=tctD; OrderedLocusNames=STM2785;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=2666399; DOI=10.1128/jb.171.8.4436-4441.1989;
RA   Widenhorn K.A., Somers J.M., Kay W.W.;
RT   "Genetic regulation of the tricarboxylate transport operon (tctI) of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 171:4436-4441(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Transcriptional activator of the tctI tricarboxylate
CC       transport system operon. {ECO:0000269|PubMed:2666399}.
CC   -!- INDUCTION: TctD expression is regulated by catabolite repression.
CC       {ECO:0000269|PubMed:2666399}.
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DR   EMBL; M28368; AAA27232.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21670.1; -; Genomic_DNA.
DR   PIR; A33861; A33861.
DR   RefSeq; NP_461711.1; NC_003197.2.
DR   RefSeq; WP_001237934.1; NC_003197.2.
DR   AlphaFoldDB; P0CL17; -.
DR   SMR; P0CL17; -.
DR   STRING; 99287.STM2785; -.
DR   PaxDb; P0CL17; -.
DR   EnsemblBacteria; AAL21670; AAL21670; STM2785.
DR   GeneID; 1254308; -.
DR   KEGG; stm:STM2785; -.
DR   PATRIC; fig|99287.12.peg.2938; -.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   OMA; RSFIVIN; -.
DR   PhylomeDB; P0CL17; -.
DR   BioCyc; SENT99287:STM2785-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..224
FT                   /note="Transcriptional regulatory protein TctD"
FT                   /id="PRO_0000081254"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        121..219
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   224 AA;  25407 MW;  DFB6D1DE013DF8CA CRC64;
     MRLLLAEDNR ELAHWLEKAL VQNGFAVDCV FDGLAADHLL HSEMYALAVL DINMPGMDGL
     EVVQRLRKRG QTLPVLLLTA RSAVADRVKG LNVGADDYLP KPFELEELDA RLRALLRRSA
     GQVHEVQQLG ELIFHDEGYF LLQGQPLALT PREQALLTVL MYRRTRPVSR QQLFEQVFSL
     NDEVSPESIE LYIHRLRKKL QGSDVRITTL RGLGYVLERG DEVG