ID   TCTP2_ARATH             Reviewed;         156 AA.
AC   Q9M9V9; F4J8E4;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Translationally controlled tumor protein 2 {ECO:0000303|PubMed:25566280};
DE            Short=AtTCTP2 {ECO:0000303|PubMed:25566280};
GN   Name=TCTP2 {ECO:0000303|PubMed:25566280};
GN   OrderedLocusNames=At3g05540 {ECO:0000312|Araport:AT3G05540};
GN   ORFNames=F18C1.20 {ECO:0000312|EMBL:AAF26143.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=25566280; DOI=10.3389/fpls.2014.00705;
RA   Toscano-Morales R., Xoconostle-Cazares B., Martinez-Navarro A.C.,
RA   Ruiz-Medrano R.;
RT   "Long distance movement of an Arabidopsis translationally controlled tumor
RT   protein (AtTCTP2) mRNA and protein in tobacco.";
RL   Front. Plant Sci. 5:705-705(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE
RP   SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF ASN-35, AND 3D-STRUCTURE
RP   MODELING.
RC   STRAIN=cv. Columbia;
RX   PubMed=26191065; DOI=10.3389/fpls.2015.00468;
RA   Toscano-Morales R., Xoconostle-Cazares B., Cabrera-Ponce J.L.,
RA   Hinojosa-Moya J., Ruiz-Salas J.L., Galvan-Gordillo S.V.,
RA   Guevara-Gonzalez R.G., Ruiz-Medrano R.;
RT   "AtTCTP2, an Arabidopsis thaliana homolog of Translationally Controlled
RT   Tumor Protein, enhances in vitro plant regeneration.";
RL   Front. Plant Sci. 6:468-468(2015).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   IDENTIFICATION AS A PSEUDOGENE.
RC   STRAIN=cv. Columbia;
RX   PubMed=19060111; DOI=10.1105/tpc.108.061010;
RA   Berkowitz O., Jost R., Pollmann S., Masle J.;
RT   "Characterization of TCTP, the translationally controlled tumor protein,
RT   from Arabidopsis thaliana.";
RL   Plant Cell 20:3430-3447(2008).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=25120549; DOI=10.3389/fpls.2014.00361;
RA   Gutierrez-Galeano D.F., Toscano-Morales R., Calderon-Perez B.,
RA   Xoconostle-Cazares B., Ruiz-Medrano R.;
RT   "Structural divergence of plant TCTPs.";
RL   Front. Plant Sci. 5:361-361(2014).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=26237533; DOI=10.1080/15592324.2015.1071003;
RA   Toscano-Morales R., Xoconostle-Cazares B., Martinez-Navarro A.C.,
RA   Ruiz-Medrano R.;
RT   "AtTCTP2 mRNA and protein movement correlates with formation of
RT   adventitious roots in tobacco.";
RL   Plant Signal. Behav. 0:0-0(2015).
CC   -!- FUNCTION: Regulates proliferation. Induces whole plant regeneration
CC       when expressed in heterologous systems (PubMed:26191065,
CC       PubMed:26237533). Involved in root growth and lateral root development,
CC       with a probable role in cell reprogramming (PubMed:25566280). The long-
CC       distance transport of TCTP RNA and/or protein in plants may have an
CC       important role in regulation of growth and development (Probable).
CC       {ECO:0000269|PubMed:25566280, ECO:0000269|PubMed:26191065,
CC       ECO:0000269|PubMed:26237533, ECO:0000305|PubMed:26237533}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25566280,
CC       ECO:0000269|PubMed:26191065, ECO:0000269|PubMed:26237533}. Cytoplasm
CC       {ECO:0000269|PubMed:25566280}.
CC   -!- TISSUE SPECIFICITY: Expressed in stems, cauline leaves, minor veins of
CC       rosette leaves, roots, lateral root primordia, vascular tissues of
CC       petioles and inflorescences, base of siliques, papillae and ovules. Not
CC       detected in root meristems, anthers or seeds (PubMed:26191065).
CC       Expressed in stomata, trichomes and root cortex (PubMed:26191065,
CC       PubMed:26237533). {ECO:0000269|PubMed:26191065,
CC       ECO:0000269|PubMed:26237533}.
CC   -!- DISRUPTION PHENOTYPE: Seedling lethality at the early rosette stage
CC       when homozygous. {ECO:0000269|PubMed:26191065}.
CC   -!- MISCELLANEOUS: In a heterologous system, TCTP2 mRNA and protein are
CC       capable of moving long distance in both directions with a tendency for
CC       movment from source to sink tissue (PubMed:25566280, PubMed:26237533).
CC       In heterografts, the long-distance transport of TCTP2 is necessary but
CC       not sufficient to induce emergence of adventitious aerial roots in
CC       close proximity to the graft (PubMed:26237533).
CC       {ECO:0000269|PubMed:25566280, ECO:0000269|PubMed:26237533}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
CC   -!- CAUTION: Was initially thought to be a pseudogene.
CC       {ECO:0000269|PubMed:19060111}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEE74255.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; KR261461; AKP17134.1; -; mRNA.
DR   EMBL; AC011620; AAF26143.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74255.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_187205.4; NM_111427.4.
DR   AlphaFoldDB; Q9M9V9; -.
DR   SMR; Q9M9V9; -.
DR   STRING; 3702.AT3G05540.1; -.
DR   PRIDE; Q9M9V9; -.
DR   GeneID; 819719; -.
DR   KEGG; ath:AT3G05540; -.
DR   Araport; AT3G05540; -.
DR   TAIR; locus:2078052; AT3G05540.
DR   eggNOG; KOG1727; Eukaryota.
DR   OrthoDB; 1439384at2759; -.
DR   PhylomeDB; Q9M9V9; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M9V9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0032502; P:developmental process; IMP:TAIR.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IMP:TAIR.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..156
FT                   /note="Translationally controlled tumor protein 2"
FT                   /id="PRO_0000434727"
FT   DOMAIN          1..156
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   MUTAGEN         35
FT                   /note="N->WVTVGAVDVNIGAN: Loss of regeneration capacity."
FT                   /evidence="ECO:0000269|PubMed:26191065"
SQ   SEQUENCE   156 AA;  18016 MW;  9C547B2EABC66A5D CRC64;
     MLVYQDILTG DELLSDSFPY KEIENGMLWE VEGKNPSGEE GGEDEGVDDQ AVKVVDIIDT
     FRLQEQPSFD KKQFVMFMKR YIKQLSPKLD SENQELFKKH IESATKFLMS KLKDFQFFVG
     ESMEGEEGSL VFAYYREGAT DPTFLYLAYG LKEIKC