ID   TCTP_ALTAL              Reviewed;         169 AA.
AC   D0MQ50;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Translationally-controlled tumor protein homolog {ECO:0000305};
DE            Short=TCTP {ECO:0000303|PubMed:19683813, ECO:0000312|EMBL:ABI26088.1};
DE   AltName: Allergen=Alt a TCTP {ECO:0000305};
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Alternaria; Alternaria alternata complex.
OX   NCBI_TaxID=5599 {ECO:0000312|EMBL:ABI26088.1};
RN   [1] {ECO:0000312|EMBL:ABI26088.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, ALLERGEN, AND CIRCULAR
RP   DICHROISM ANALYSIS.
RC   TISSUE=Mycelium {ECO:0000303|PubMed:19683813};
RX   PubMed=19683813; DOI=10.1016/j.molimm.2009.07.024;
RA   Rid R., Onder K., MacDonald S., Lang R., Hawranek T., Ebner C., Hemmer W.,
RA   Richter K., Simon-Nobbe B., Breitenbach M.;
RT   "Alternaria alternata TCTP, a novel cross-reactive ascomycete allergen.";
RL   Mol. Immunol. 46:3476-3487(2009).
CC   -!- FUNCTION: Involved in protein synthesis. Involved in microtubule
CC       stabilization. {ECO:0000250|UniProtKB:P35691}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P35691}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in
CC       approximately 4% of patients tested allergic to A.alternata.
CC       {ECO:0000269|PubMed:19683813}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; DQ837161; ABI26088.1; -; mRNA.
DR   AlphaFoldDB; D0MQ50; -.
DR   SMR; D0MQ50; -.
DR   Allergome; 8237; Alt a TCTP.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR   GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Cytoskeleton; Microtubule; Protein biosynthesis.
FT   CHAIN           1..169
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000446896"
FT   DOMAIN          1..169
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ   SEQUENCE   169 AA;  18889 MW;  D9880C61F3B36245 CRC64;
     MLIYKDILTG DEIISDSYNL KEIDGVVYEA DCTKITVGGE SFDTGANASA EEQEEGAEDS
     AETKIDVVYS FRLNETGFDK KGYLTYLKGY MKAVKDGLKK KGADEATIKD FETKASGYAK
     KIISNFKDYE FFTGESMNPD GMIVLLNYRE DGVTPYVTVW KHGLEEMKV