ID   TCTP_CAEEL              Reviewed;         181 AA.
AC   Q93573;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=TCTP;
GN   Name=tct-1; ORFNames=F25H2.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-19.
RC   STRAIN=Bristol N2;
RX   PubMed=9150941; DOI=10.1002/elps.1150180337;
RA   Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.;
RT   "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates
RT   and identification of protein spots by microsequencing.";
RL   Electrophoresis 18:557-562(1997).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; Z79754; CAB02099.1; -; Genomic_DNA.
DR   PIR; T21352; T21352.
DR   RefSeq; NP_492767.1; NM_060366.5.
DR   PDB; 2KWB; NMR; -; A=1-181.
DR   PDB; 2LOY; NMR; -; A=1-181.
DR   PDBsum; 2KWB; -.
DR   PDBsum; 2LOY; -.
DR   AlphaFoldDB; Q93573; -.
DR   BMRB; Q93573; -.
DR   SMR; Q93573; -.
DR   BioGRID; 38358; 98.
DR   DIP; DIP-26025N; -.
DR   IntAct; Q93573; 1.
DR   STRING; 6239.F25H2.11; -.
DR   iPTMnet; Q93573; -.
DR   World-2DPAGE; 0020:Q93573; -.
DR   EPD; Q93573; -.
DR   PaxDb; Q93573; -.
DR   PeptideAtlas; Q93573; -.
DR   EnsemblMetazoa; F25H2.11.1; F25H2.11.1; WBGene00009122.
DR   GeneID; 172944; -.
DR   UCSC; F25H2.11.1; c. elegans.
DR   CTD; 172944; -.
DR   WormBase; F25H2.11; CE09656; WBGene00009122; tct-1.
DR   eggNOG; KOG1727; Eukaryota.
DR   GeneTree; ENSGT00390000006051; -.
DR   HOGENOM; CLU_095877_1_1_1; -.
DR   InParanoid; Q93573; -.
DR   OMA; IVYEADC; -.
DR   OrthoDB; 1439384at2759; -.
DR   PhylomeDB; Q93573; -.
DR   EvolutionaryTrace; Q93573; -.
DR   PRO; PR:Q93573; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00009122; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:WormBase.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calcium; Cytoplasm; Direct protein sequencing;
KW   Reference proteome.
FT   CHAIN           1..181
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000211281"
FT   DOMAIN          1..181
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   STRAND          2..8
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   TURN            10..12
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          14..16
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          21..23
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   TURN            24..26
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          27..31
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:2LOY"
FT   HELIX           61..63
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          65..68
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   HELIX           69..72
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   TURN            73..75
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          76..79
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   HELIX           81..106
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   HELIX           110..127
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   HELIX           130..133
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          137..141
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   HELIX           142..147
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          153..161
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          164..172
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   TURN            173..175
FT                   /evidence="ECO:0007829|PDB:2KWB"
FT   STRAND          176..179
FT                   /evidence="ECO:0007829|PDB:2KWB"
SQ   SEQUENCE   181 AA;  20542 MW;  112E23374D29DA12 CRC64;
     MLIYKDIFTD DELSSDSFPM KLVDDLVYEF KGKHVVRKEG EIVLAGSNPS AEEGAEDDGS
     DEHVERGIDI VLNHKLVEMN CYEDASMFKA YIKKFMKNVI DHMEKNNRDK ADVDAFKKKI
     QGWVVSLLAK DRFKNLAFFI GERAAEGAEN GQVAIIEYRD VDGTEVPTLM LVKEAIIEEK
     C