TCTP_CROAD
ID TCTP_CROAD Reviewed; 172 AA.
AC J3SFJ3;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 1.
DT 25-MAY-2022, entry version 20.
DE RecName: Full=Translationally-controlled tumor protein homolog;
DE Short=TCTP;
OS Crotalus adamanteus (Eastern diamondback rattlesnake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=8729;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=23025625; DOI=10.1186/1471-2164-13-312;
RA Rokyta D.R., Lemmon A.R., Margres M.J., Aronow K.;
RT "The venom-gland transcriptome of the eastern diamondback rattlesnake
RT (Crotalus adamanteus).";
RL BMC Genomics 13:312-312(2012).
CC -!- FUNCTION: Venom protein that causes edema, enhances vascular
CC permeability and is likely related to the inflammatory activity of the
CC venom. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MISCELLANEOUS: Secretion of this protein from cells may proceed via an
CC ER/Golgi-independent pathway, probably mediated by secreted vesicles
CC called exosomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC ProRule:PRU01133}.
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DR EMBL; JU176353; AFJ51876.1; -; mRNA.
DR AlphaFoldDB; J3SFJ3; -.
DR SMR; J3SFJ3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.170.150.10; -; 1.
DR InterPro; IPR011057; Mss4-like_sf.
DR InterPro; IPR011323; Mss4/transl-control_tumour.
DR InterPro; IPR034737; TCTP.
DR InterPro; IPR018103; Translation_control_tumour_CS.
DR InterPro; IPR018105; Translational_control_tumour_p.
DR PANTHER; PTHR11991; PTHR11991; 1.
DR Pfam; PF00838; TCTP; 1.
DR PRINTS; PR01653; TCTPROTEIN.
DR SUPFAM; SSF51316; SSF51316; 1.
DR PROSITE; PS01002; TCTP_1; 1.
DR PROSITE; PS01003; TCTP_2; 1.
DR PROSITE; PS51797; TCTP_3; 1.
PE 2: Evidence at transcript level;
KW Secreted.
FT CHAIN 1..172
FT /note="Translationally-controlled tumor protein homolog"
FT /id="PRO_0000429459"
FT DOMAIN 1..172
FT /note="TCTP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ SEQUENCE 172 AA; 19433 MW; 5FC5CB782045AC3B CRC64;
MIIYRDCISQ DEMFSDIYKI TEVANGLCLE VEGKMVSRKE GEIDDALIGG NASAEGPEGD
GTEATVITGV DIVMNHHLQE TSFTKESYKK YIKDYMKSIK ARLEETKPER VKPFMTGAAE
QVKHILGNFK NYQFFVGENM NPDGMVGLLD FREDGVTPYM IFFKDGLEME KC