ID   TCTP_CROHD              Reviewed;         172 AA.
AC   T1DKS4;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=TCTP;
OS   Crotalus horridus (Timber rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=35024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA   Rokyta D.R., Wray K.P., Margres M.J.;
RT   "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT   (Crotalus horridus) revealed through comparative venom-gland
RT   transcriptomics.";
RL   BMC Genomics 14:394-394(2013).
CC   -!- FUNCTION: Venom protein that causes edema, enhances vascular
CC       permeability and is likely related to the inflammatory activity of the
CC       venom. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Secretion of this protein from cells may proceed via an
CC       ER/Golgi-independent pathway, probably mediated by secreted vesicles
CC       called exosomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; GAAZ01002497; JAA95446.1; -; mRNA.
DR   AlphaFoldDB; T1DKS4; -.
DR   SMR; T1DKS4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000429460"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ   SEQUENCE   172 AA;  19433 MW;  5FC5CB782045AC3B CRC64;
     MIIYRDCISQ DEMFSDIYKI TEVANGLCLE VEGKMVSRKE GEIDDALIGG NASAEGPEGD
     GTEATVITGV DIVMNHHLQE TSFTKESYKK YIKDYMKSIK ARLEETKPER VKPFMTGAAE
     QVKHILGNFK NYQFFVGENM NPDGMVGLLD FREDGVTPYM IFFKDGLEME KC