ID   TCTP_DAVTA              Reviewed;         169 AA.
AC   A1KXP4;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Translationally-controlled tumor protein homolog {ECO:0000305};
DE            Short=TCTP {ECO:0000303|PubMed:17645945};
DE   AltName: Allergen=Cla h TCTP {ECO:0000305};
OS   Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Cladosporiales; Cladosporiaceae; Cladosporium.
OX   NCBI_TaxID=29918 {ECO:0000312|EMBL:AAR08428.1};
RN   [1] {ECO:0000312|EMBL:AAR08428.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, ALLERGEN, AND CIRCULAR
RP   DICHROISM ANALYSIS.
RX   PubMed=17645945; DOI=10.1016/j.molimm.2007.06.002;
RA   Rid R., Simon-Nobbe B., Langdon J., Holler C., Wally V., Poll V., Ebner C.,
RA   Hemmer W., Hawranek T., Lang R., Richter K., Macdonald S., Rinnerthaler M.,
RA   Laun P., Mari A., Breitenbach M.;
RT   "Cladosporium herbarum translationally controlled tumor protein (TCTP) is
RT   an IgE-binding antigen and is associated with disease severity.";
RL   Mol. Immunol. 45:406-418(2008).
CC   -!- FUNCTION: Involved in protein synthesis. Involved in microtubule
CC       stabilization. {ECO:0000250|UniProtKB:P35691}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P35691}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE in 3% of
CC       306 C.herbarum-allergic patients tested. Patients reactive to this
CC       protein seem to have a higher probability to suffer from asthma than
CC       other patients allergic to C.herbarum. Induces histamine release from
CC       human basophils. {ECO:0000269|PubMed:17645945}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; AY349609; AAR08428.1; -; mRNA.
DR   AlphaFoldDB; A1KXP4; -.
DR   SMR; A1KXP4; -.
DR   Allergome; 3815; Cla h TCTP.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR   GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Cytoskeleton; Microtubule; Protein biosynthesis.
FT   CHAIN           1..169
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000446897"
FT   DOMAIN          1..169
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ   SEQUENCE   169 AA;  18726 MW;  7FE76C96469A1D6E CRC64;
     MLIYNDIISG DELISDSYDL VEVDGVAYEA DCRKITIGGE TFDTGANASA EGGDEEADDQ
     KETKIDVVHA FQLQETNFDK KAYLGHLKSY MKKIKESMAA SGASEDEVKE FEKGAQTFAK
     RVVGSFKDYE FLIGPSMDPD AMVVLLNYRE DGVTPYVTLW KHGLKSTKV