ID   TCTP_DROPS              Reviewed;         172 AA.
AC   Q293Y0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=TCTP;
GN   Name=Tctp; ORFNames=GA18441;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; CM000070; EAL29084.1; -; Genomic_DNA.
DR   RefSeq; XP_001359932.1; XM_001359895.4.
DR   AlphaFoldDB; Q293Y0; -.
DR   SMR; Q293Y0; -.
DR   STRING; 7237.FBpp0284864; -.
DR   EnsemblMetazoa; FBtr0286426; FBpp0284864; FBgn0078443.
DR   GeneID; 4803141; -.
DR   KEGG; dpo:Dpse_GA18441; -.
DR   eggNOG; KOG1727; Eukaryota.
DR   HOGENOM; CLU_095877_0_1_1; -.
DR   InParanoid; Q293Y0; -.
DR   OMA; IVYEADC; -.
DR   PhylomeDB; Q293Y0; -.
DR   ChiTaRS; Tctp; fly.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0078443; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEA:EnsemblMetazoa.
DR   GO; GO:0006302; P:double-strand break repair; IEA:EnsemblMetazoa.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR   GO; GO:0033129; P:positive regulation of histone phosphorylation; IEA:EnsemblMetazoa.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR   GO; GO:2000736; P:regulation of stem cell differentiation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   3: Inferred from homology;
KW   Calcium; Cytoplasm; Reference proteome.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000252308"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ   SEQUENCE   172 AA;  19529 MW;  33C31777860F01E7 CRC64;
     MKIFKDIITG DEMFADTYKI KLVDDVVYEV YGKLISREGS EIKLEGANAS AEEADEGTDT
     NVESGVDVVL NHRLVECFAF GDKKSYTLYL KDYMKKVLAK LAEKSPDQVD VFKTNMNKAM
     KDILGRFKEL QFFTGESMDC DGMVALVEYR EIDGQSIPVL MFFKHGLEEE KC