ID   TCTP_DROYA              Reviewed;         172 AA.
AC   Q6XIN1; Q6XHY0;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=TCTP;
GN   Name=Tctp {ECO:0000250|UniProtKB:Q9VGS2}; ORFNames=GE26077;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:AAR09822.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14525923; DOI=10.1101/gr.1311003;
RA   Domazet-Loso T., Tautz D.;
RT   "An evolutionary analysis of orphan genes in Drosophila.";
RL   Genome Res. 13:2213-2219(2003).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250|UniProtKB:P13693}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13693}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; AY231799; AAR09822.1; -; mRNA.
DR   EMBL; AY232052; AAR10075.1; -; mRNA.
DR   AlphaFoldDB; Q6XIN1; -.
DR   SMR; Q6XIN1; -.
DR   STRING; 7245.FBpp0271087; -.
DR   eggNOG; KOG1727; Eukaryota.
DR   ChiTaRS; Tctp; fly.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEA:EnsemblMetazoa.
DR   GO; GO:0006302; P:double-strand break repair; IEA:EnsemblMetazoa.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR   GO; GO:0033129; P:positive regulation of histone phosphorylation; IEA:EnsemblMetazoa.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR   GO; GO:2000736; P:regulation of stem cell differentiation; IEA:EnsemblMetazoa.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cytoplasm.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000232400"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   CONFLICT        147
FT                   /note="V -> R (in Ref. 1; AAR10075)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   172 AA;  19650 MW;  DD2DAF8E1EC07A09 CRC64;
     MKIYKDIITG DEMFADTYKM KLVDEVIYEV YGKLITRQGD DIKLEGANAS AEEADEGTDI
     TSESGVDVVL NHRLQECFAF GDKKSYTLYL KDYMKKVLAK LEEKSPDQVD VFKTNMNKAM
     KDILGRFKEL QFFTGESMDC DGMVALVEYR EINGDSVPVL MFFKHGLDEE KC