ID   TCTP_LOXIN              Reviewed;         172 AA.
AC   G3LU44;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=LiTCTP;
DE   AltName: Full=Histamine-releasing factor;
DE            Short=HRF;
OS   Loxosceles intermedia (Brown spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Haplogynae; Scytodoidea; Sicariidae; Loxosceles.
OX   NCBI_TaxID=58218;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=22051631; DOI=10.1016/j.biocel.2011.10.013;
RA   Sade Y.B., Boia-Ferreira M., Gremski L.H., da Silveira R.B., Gremski W.,
RA   Senff-Ribeiro A., Chaim O.M., Veiga S.S.;
RT   "Molecular cloning, heterologous expression and functional characterization
RT   of a novel translationally-controlled tumor protein (TCTP) family member
RT   from Loxosceles intermedia (brown spider) venom.";
RL   Int. J. Biochem. Cell Biol. 44:170-177(2012).
CC   -!- FUNCTION: Venom protein that causes edema, enhances vascular
CC       permeability and is likely related to the inflammatory activity of the
CC       venom. {ECO:0000269|PubMed:22051631}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Secretion of this protein from cells may proceed via an
CC       ER/Golgi-independent pathway, probably mediated by secreted vesicles
CC       called exosomes. {ECO:0000305|PubMed:22051631}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; JN544929; AEN55462.1; -; mRNA.
DR   AlphaFoldDB; G3LU44; -.
DR   SMR; G3LU44; -.
DR   ArachnoServer; AS001612; TCTP1-1-Loxosceles intermedia.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000425848"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
SQ   SEQUENCE   172 AA;  19737 MW;  0E0EAC809E3C59AF CRC64;
     MIIFKDLLTG DEMFTDSSKY KVVDGCLYEV ECRHISRRHG DIQLDGANPS QEEADEATDD
     IVESGLDLVL NQRLIETGFS KNDYKVYLKG YTKALQDKWK EMEKSESEIN EAKTKLTEAV
     KKVLPKLSDL QFFMGESSNP DGLIALLEYR QVDEKEVPIM MFFKHGLDEE KV