TCTP_PLAF7
ID TCTP_PLAF7 Reviewed; 171 AA.
AC Q8I3Z5;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Translationally-controlled tumor protein homolog;
DE Short=TCTP;
GN Name=TCTP; ORFNames=PFE0545c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC ProRule:PRU01133}.
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DR EMBL; AL844504; CAD51474.1; -; Genomic_DNA.
DR RefSeq; XP_001351667.1; XM_001351631.1.
DR PDB; 3P3K; X-ray; 2.55 A; A=1-171.
DR PDBsum; 3P3K; -.
DR AlphaFoldDB; Q8I3Z5; -.
DR SMR; Q8I3Z5; -.
DR BioGRID; 1208150; 1.
DR IntAct; Q8I3Z5; 2.
DR STRING; 5833.PFE0545c; -.
DR DrugBank; DB11638; Artenimol.
DR PRIDE; Q8I3Z5; -.
DR EnsemblProtists; CAD51474; CAD51474; PF3D7_0511000.
DR GeneID; 812831; -.
DR KEGG; pfa:PF3D7_0511000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0511000; -.
DR HOGENOM; CLU_095877_0_1_1; -.
DR InParanoid; Q8I3Z5; -.
DR OMA; IVYEADC; -.
DR PhylomeDB; Q8I3Z5; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0020020; C:food vacuole; IDA:GeneDB.
DR GO; GO:0005509; F:calcium ion binding; IDA:GeneDB.
DR Gene3D; 2.170.150.10; -; 1.
DR InterPro; IPR011057; Mss4-like_sf.
DR InterPro; IPR011323; Mss4/transl-control_tumour.
DR InterPro; IPR034737; TCTP.
DR InterPro; IPR018103; Translation_control_tumour_CS.
DR InterPro; IPR018105; Translational_control_tumour_p.
DR PANTHER; PTHR11991; PTHR11991; 1.
DR Pfam; PF00838; TCTP; 1.
DR PRINTS; PR01653; TCTPROTEIN.
DR SUPFAM; SSF51316; SSF51316; 1.
DR PROSITE; PS01003; TCTP_2; 1.
DR PROSITE; PS51797; TCTP_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Cytoplasm; Reference proteome.
FT CHAIN 1..171
FT /note="Translationally-controlled tumor protein homolog"
FT /id="PRO_0000211291"
FT DOMAIN 1..171
FT /note="TCTP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT STRAND 1..6
FT /evidence="ECO:0007829|PDB:3P3K"
FT TURN 7..9
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 12..15
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 27..31
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 33..37
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 70..74
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 84..105
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 107..109
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 110..126
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 128..130
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 132..135
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 158..162
FT /evidence="ECO:0007829|PDB:3P3K"
FT HELIX 163..165
FT /evidence="ECO:0007829|PDB:3P3K"
FT STRAND 166..171
FT /evidence="ECO:0007829|PDB:3P3K"
SQ SEQUENCE 171 AA; 19979 MW; AA6A6FB40CB52FFF CRC64;
MKVFKDVFTN DEVCSDSYVQ QDPFEVPEFR EIAFEVKSNK RIKGNEDYGI ADNSEDAVEG
MGADVEHVID IVDSFQLTST AFSKKEYSAY IKNYMQKVAK YLEEKKPDRV EIFKTKAQPF
IKHILTNFDD FEFYMGESLD MEAGIIYSYY KGEEITPRFV YISDGLFEEK Y
