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TCTP_PLAYO
ID   TCTP_PLAYO              Reviewed;         171 AA.
AC   Q9XYU2; Q7RF15;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Translationally-controlled tumor protein homolog;
DE            Short=TCTP;
GN   Name=TCTP; ORFNames=PY04896;
OS   Plasmodium yoelii yoelii.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=73239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17XNL;
RX   PubMed=12368865; DOI=10.1038/nature01099;
RA   Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C.,
RA   Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M.,
RA   Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E.,
RA   Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M.,
RA   Shoaibi A., Cummings L.M., Florens L., Yates J.R. III, Raine J.D.,
RA   Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W.,
RA   Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R.,
RA   Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J.,
RA   Carucci D.J.;
RT   "Genome sequence and comparative analysis of the model rodent malaria
RT   parasite Plasmodium yoelii yoelii.";
RL   Nature 419:512-519(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-163.
RX   PubMed=10639360; DOI=10.1128/aac.44.2.344-347.2000;
RA   Walker D.J., Pitsch J.L., Peng M.M., Robinson B.L., Peters W.,
RA   Bhisutthibhan J., Meshnick S.R.;
RT   "Mechanisms of artemisinin resistance in the rodent malaria pathogen
RT   Plasmodium yoelii.";
RL   Antimicrob. Agents Chemother. 44:344-347(2000).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: Seems to be one of the target of artemisinin.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; AABL01001515; EAA16837.1; -; Genomic_DNA.
DR   EMBL; AF124820; AAD28740.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9XYU2; -.
DR   SMR; Q9XYU2; -.
DR   STRING; 73239.Q9XYU2; -.
DR   EnsemblProtists; EAA16837; EAA16837; EAA16837.
DR   InParanoid; Q9XYU2; -.
DR   OMA; IVYEADC; -.
DR   Proteomes; UP000008553; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   3: Inferred from homology;
KW   Calcium; Cytoplasm; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Translationally-controlled tumor protein homolog"
FT                   /id="PRO_0000211293"
FT   DOMAIN          1..171
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   CONFLICT        27
FT                   /note="P -> A (in Ref. 2; AAD28740)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   171 AA;  19901 MW;  1B72404C7F2B5C64 CRC64;
     MKVYKDIFTN DEVCSDSYIQ EDPFGNPEFR EIAFEVKSNK RIKGNDDYGI ADNSEDAVDG
     MGADVEHVID IVDSFQLTST SLSKKEYSAY VKNFMQRILK HLEEKKPDRV DIFKTKAQPL
     IKHILTNFDD FEFYMGESLD MEAGLIYSYY KGEEITPRFV YISDGLFEEK Y
 
 
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