ID   TCTP_RABIT              Reviewed;         172 AA.
AC   P43348; O77730; Q9MYT9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Translationally-controlled tumor protein;
DE            Short=TCTP;
GN   Name=TPT1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RA   Dawson S.P., Martin M., Tighe P.J., Wilde C.J., Mayer R.J.;
RT   "A rabbit gene encoding a protein homologous to a translationally
RT   controlled human tumour protein undergoes developmental regulation during
RT   mammary gland development.";
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Heart;
RX   PubMed=9799103; DOI=10.1046/j.1432-1327.1998.2570062.x;
RA   Thiele H., Berger M., Lenzner C., Kuhn H., Thiele B.-J.;
RT   "Structure of the promoter and complete sequence of the gene coding for the
RT   rabbit translationally controlled tumor protein (TCTP) P23.";
RL   Eur. J. Biochem. 257:62-68(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS.
RX   PubMed=10951206; DOI=10.1046/j.1432-1327.2000.01609.x;
RA   Thiele H., Berger M., Skalweit A., Thiele B.-J.;
RT   "Expression of the gene and processed pseudogenes encoding the human and
RT   rabbit translationally controlled tumor protein (TCTP).";
RL   Eur. J. Biochem. 267:5473-5481(2000).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STEAP3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Undergoes developmental regulation during mammary
CC       gland development.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z46805; CAA86826.1; -; mRNA.
DR   EMBL; AJ225898; CAA12650.1; -; Genomic_DNA.
DR   EMBL; AJ131951; CAB41990.1; -; mRNA.
DR   EMBL; AJ277092; CAC01239.1; -; mRNA.
DR   EMBL; AJ277093; CAC01240.1; -; mRNA.
DR   PIR; A38956; A38956.
DR   RefSeq; NP_001075598.1; NM_001082129.2.
DR   RefSeq; XP_002709520.1; XM_002709474.3.
DR   RefSeq; XP_002718363.1; XM_002718317.3.
DR   RefSeq; XP_002720179.1; XM_002720133.3.
DR   AlphaFoldDB; P43348; -.
DR   BMRB; P43348; -.
DR   SMR; P43348; -.
DR   STRING; 9986.ENSOCUP00000018089; -.
DR   Ensembl; ENSOCUT00000023699; ENSOCUP00000037603; ENSOCUG00000024148.
DR   Ensembl; ENSOCUT00000042080; ENSOCUP00000033026; ENSOCUG00000023692.
DR   GeneID; 100008854; -.
DR   GeneID; 100344007; -.
DR   GeneID; 100353956; -.
DR   GeneID; 100357892; -.
DR   KEGG; ocu:100008854; -.
DR   KEGG; ocu:100344007; -.
DR   KEGG; ocu:100353956; -.
DR   KEGG; ocu:100357892; -.
DR   CTD; 7178; -.
DR   eggNOG; KOG1727; Eukaryota.
DR   GeneTree; ENSGT00390000006051; -.
DR   HOGENOM; CLU_095877_0_1_1; -.
DR   InParanoid; P43348; -.
DR   OrthoDB; 1439384at2759; -.
DR   TreeFam; TF300238; -.
DR   Proteomes; UP000001811; Chromosome 8.
DR   Proteomes; UP000001811; Chromosome X.
DR   Bgee; ENSOCUG00000023692; Expressed in blood and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein"
FT                   /id="PRO_0000211271"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   MOD_RES         46
FT                   /note="Phosphoserine; by PLK1"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
FT   MOD_RES         64
FT                   /note="Phosphoserine; by PLK1"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
FT   VARIANT         79
FT                   /note="Q -> R"
FT   VARIANT         153
FT                   /note="E -> G"
FT   VARIANT         169
FT                   /note="M -> V"
FT   CONFLICT        4
FT                   /note="Y -> D (in Ref. 1; CAA86826)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="M -> T (in Ref. 1; CAA86826)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        129
FT                   /note="F -> L (in Ref. 1; CAA86826)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   172 AA;  19537 MW;  7E3209A92C601452 CRC64;
     MIIYRDLISH DEMFSDIYKI REIAGGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE
     GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE
     QIKHILANFK NYQFYIGENM NPDGMVALLD YREDGVTPFM IFFKDGLEME KC