ID   TCTP_RAT                Reviewed;         172 AA.
AC   P63029; P14701;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Translationally-controlled tumor protein;
DE            Short=TCTP;
DE   AltName: Full=Lens epithelial protein;
GN   Name=Tpt1; Synonyms=Trt;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Lens;
RA   Wen Y., Li G., Chen P., Bekhor I.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 6-34 AND 111-123, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain, and Hippocampus;
RA   Lubec G., Chen W.-Q., Kang S.U.;
RL   Submitted (JUL-2007) to UniProtKB.
RN   [4]
RP   SELF-INTERACTION.
RX   PubMed=11368327; DOI=10.1006/abbi.2000.2108;
RA   Yoon T., Jung J., Kim M., Lee K.M., Choi E.C., Lee K.;
RT   "Identification of the self-interaction of rat TCTP/IgE-dependent
RT   histamine-releasing factor using yeast two-hybrid system.";
RL   Arch. Biochem. Biophys. 384:379-382(2000).
RN   [5]
RP   CALCIUM-BINDING.
RX   PubMed=11156187; DOI=10.1007/bf02975253;
RA   Kim M., Jung Y., Lee K., Kim C.;
RT   "Identification of the calcium binding sites in translationally controlled
RT   tumor protein.";
RL   Arch. Pharm. Res. 23:633-636(2000).
CC   -!- FUNCTION: Involved in calcium binding and microtubule stabilization.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STEAP3 (By similarity). Seems to self-interact.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01133}.
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DR   EMBL; U20525; AAA62507.1; -; mRNA.
DR   EMBL; BC086358; AAH86358.1; -; mRNA.
DR   RefSeq; NP_446319.1; NM_053867.1.
DR   AlphaFoldDB; P63029; -.
DR   SMR; P63029; -.
DR   IntAct; P63029; 4.
DR   MINT; P63029; -.
DR   STRING; 10116.ENSRNOP00000001383; -.
DR   iPTMnet; P63029; -.
DR   PhosphoSitePlus; P63029; -.
DR   SwissPalm; P63029; -.
DR   World-2DPAGE; 0004:P63029; -.
DR   jPOST; P63029; -.
DR   PaxDb; P63029; -.
DR   PRIDE; P63029; -.
DR   Ensembl; ENSRNOT00000001383; ENSRNOP00000001383; ENSRNOG00000001049.
DR   GeneID; 116646; -.
DR   KEGG; rno:116646; -.
DR   UCSC; RGD:621623; rat.
DR   CTD; 7178; -.
DR   RGD; 621623; Tpt1.
DR   eggNOG; KOG1727; Eukaryota.
DR   GeneTree; ENSGT00390000006051; -.
DR   HOGENOM; CLU_095877_0_1_1; -.
DR   InParanoid; P63029; -.
DR   OMA; IVYEADC; -.
DR   OrthoDB; 1439384at2759; -.
DR   PhylomeDB; P63029; -.
DR   TreeFam; TF300238; -.
DR   PRO; PR:P63029; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000001049; Expressed in thymus and 19 other tissues.
DR   Genevisible; P63029; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005771; C:multivesicular body; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISO:RGD.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:RGD.
DR   GO; GO:0008283; P:cell population proliferation; TAS:RGD.
DR   GO; GO:2000384; P:negative regulation of ectoderm development; ISO:RGD.
DR   GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; ISO:RGD.
DR   GO; GO:0009615; P:response to virus; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR   GO; GO:0019827; P:stem cell population maintenance; ISO:RGD.
DR   Gene3D; 2.170.150.10; -; 1.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   InterPro; IPR011323; Mss4/transl-control_tumour.
DR   InterPro; IPR034737; TCTP.
DR   InterPro; IPR018103; Translation_control_tumour_CS.
DR   InterPro; IPR018105; Translational_control_tumour_p.
DR   PANTHER; PTHR11991; PTHR11991; 1.
DR   Pfam; PF00838; TCTP; 1.
DR   PRINTS; PR01653; TCTPROTEIN.
DR   SUPFAM; SSF51316; SSF51316; 1.
DR   PROSITE; PS01002; TCTP_1; 1.
DR   PROSITE; PS01003; TCTP_2; 1.
DR   PROSITE; PS51797; TCTP_3; 1.
PE   1: Evidence at protein level;
KW   Calcium; Cytoplasm; Direct protein sequencing; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..172
FT                   /note="Translationally-controlled tumor protein"
FT                   /id="PRO_0000211272"
FT   DOMAIN          1..172
FT                   /note="TCTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01133"
FT   MOD_RES         46
FT                   /note="Phosphoserine; by PLK1"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
FT   MOD_RES         64
FT                   /note="Phosphoserine; by PLK1"
FT                   /evidence="ECO:0000250|UniProtKB:P13693"
SQ   SEQUENCE   172 AA;  19462 MW;  7F46751DA2D281D2 CRC64;
     MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG NASAEGPEGE
     GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK GKLEEQKPER VKPFMTGAAE
     QIKHILANFN NYQFFIGENM NPDGMVALLD YREDGVTPFM IFFKDGLEME KC