ID   TDA11_KLULA             Reviewed;         442 AA.
AC   Q6CN40;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Topoisomerase I damage affected protein 11;
GN   Name=TDA11; OrderedLocusNames=KLLA0E15489g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDA11 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAG99736.1; -; Genomic_DNA.
DR   RefSeq; XP_454649.1; XM_454649.1.
DR   AlphaFoldDB; Q6CN40; -.
DR   SMR; Q6CN40; -.
DR   EnsemblFungi; CAG99736; CAG99736; KLLA0_E15489g.
DR   GeneID; 2894706; -.
DR   KEGG; kla:KLLA0_E15489g; -.
DR   HOGENOM; CLU_619735_0_0_1; -.
DR   InParanoid; Q6CN40; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031388; Tda11.
DR   Pfam; PF17084; TDA11; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..442
FT                   /note="Topoisomerase I damage affected protein 11"
FT                   /id="PRO_0000410757"
FT   REGION          16..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          270..300
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        33..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  48146 MW;  1E9659E0370B286B CRC64;
     MDRDVLEKFI DLQDKENDID TKSKIYHEVT DRGSVTPTFN QGSSGMSPKS VGSSGRNKNI
     QLQLTPTKAD PTSTLDSHPL KGDNSDQDDI TGNMKENEDD VSLGSGKVTV KNNGNGVSAA
     TNGKGGNQEL GIRRSNTWKR KSLIMPLMSP EHTVKQQQRQ SYQQHCKPSE SVSNTPLGRK
     YRSKLDRNDG QKSVRSSISS IGSLLPDGAT TEFSASPATK LKLPTTTTDT AKVVPSVSED
     DNDMESLLQS LANKELEILE RTRRVHDLFR QIKIEDKIIK QNAEELQQLK KKVSRLVGNQ
     VQGQNSNTTL PAESHGESNN AETADNKSSS LWTKSVSLLN QFDQIIQGTV ETKLGLGDSG
     SSATENQSEG KPKGDDNAGS AIWSLVNEFK NGLGLLATEE EDADGSIGTI ATGLATNMED
     YGTRKAESST QAKEIEMYHY SH