ID   TDA11_LACTC             Reviewed;         379 AA.
AC   C5DDJ3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Topoisomerase I damage affected protein 11;
GN   Name=TDA11; OrderedLocusNames=KLTH0C01452g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDA11 family. {ECO:0000305}.
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DR   EMBL; CU928167; CAR21854.1; -; Genomic_DNA.
DR   RefSeq; XP_002552292.1; XM_002552246.1.
DR   AlphaFoldDB; C5DDJ3; -.
DR   SMR; C5DDJ3; -.
DR   STRING; 559295.C5DDJ3; -.
DR   EnsemblFungi; CAR21854; CAR21854; KLTH0C01452g.
DR   GeneID; 8291150; -.
DR   KEGG; lth:KLTH0C01452g; -.
DR   eggNOG; ENOG502S2SD; Eukaryota.
DR   HOGENOM; CLU_046807_0_0_1; -.
DR   InParanoid; C5DDJ3; -.
DR   OMA; WSFVSDV; -.
DR   OrthoDB; 1540211at2759; -.
DR   Proteomes; UP000002036; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031388; Tda11.
DR   Pfam; PF17084; TDA11; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..379
FT                   /note="Topoisomerase I damage affected protein 11"
FT                   /id="PRO_0000410758"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          332..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          125..190
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  41694 MW;  0E1BAD23F7CC9004 CRC64;
     MSKLDGFIEE HDRESNIDSG ARLESTKPSP KVGSPAQRVR QNGVKSPILQ TQATPAKPSE
     QEHPLKETPT RATAGGKMTR SNTLKRLSLI QPVISPETTP KEHRQQQATR NRSRSVVSVH
     SRSSSSASEQ LADATKDVNA LLQLLANKEL ELLETKHKIE ELKKTLTQEE KALLRQTHEL
     QDLKTQVGKA LNSGIDEQIQ QQSQSSHHSP NQRSLAVPTS HTPGNESRPA HAKKESVWTK
     PLSFLNQFDQ LIQHELEKKL NWDDVASPEK TPGAESGTLS GRSASPASYN NGNSNNNNNN
     NSNRGRPNED VLGNMSSSLW SFVSDVKTGL LGINEEEEEE SAEAPAVASS GESNNQLRFV
     GSKNNSEVEL KEYNASKRQ