ID   TDA2_CANGA              Reviewed;         112 AA.
AC   Q6FPK1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Topoisomerase I damage affected protein 2;
GN   Name=TDA2; OrderedLocusNames=CAGL0J03190g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40045}. Cell
CC       projection {ECO:0000250|UniProtKB:P40045}. Note=Concentrates at
CC       cytoplasmic punctate structures and localizes at the mating projection
CC       tip. {ECO:0000250|UniProtKB:P40045}.
CC   -!- SIMILARITY: Belongs to the TDA2 family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG60792.1; -; Genomic_DNA.
DR   RefSeq; XP_447843.1; XM_447843.1.
DR   AlphaFoldDB; Q6FPK1; -.
DR   SMR; Q6FPK1; -.
DR   STRING; 5478.XP_447843.1; -.
DR   EnsemblFungi; CAG60792; CAG60792; CAGL0J03190g.
DR   GeneID; 2889730; -.
DR   KEGG; cgr:CAGL0J03190g; -.
DR   CGD; CAL0133432; CAGL0J03190g.
DR   VEuPathDB; FungiDB:CAGL0J03190g; -.
DR   eggNOG; ENOG502S7YH; Eukaryota.
DR   HOGENOM; CLU_137494_1_0_1; -.
DR   InParanoid; Q6FPK1; -.
DR   OMA; ITIIWIS; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0110131; C:Aim21-Tda2 complex; IEA:EnsemblFungi.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:EnsemblFungi.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:EnsemblFungi.
DR   GO; GO:2000813; P:negative regulation of barbed-end actin filament capping; IEA:EnsemblFungi.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR005334; Tctex-1-like.
DR   InterPro; IPR038586; Tctex-1-like_sf.
DR   Pfam; PF03645; Tctex-1; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Reference proteome.
FT   CHAIN           1..112
FT                   /note="Topoisomerase I damage affected protein 2"
FT                   /id="PRO_0000410729"
SQ   SEQUENCE   112 AA;  12416 MW;  F5A67D898326D97B CRC64;
     MVIEKIDDKS SNSPLTAPRL IDLIESQFSE SQVSADTLIQ HILESLNKHS SQYKYIVSVT
     SIDIPTESSS SCEIDNKFGA SWNAKKDGFL THVLEDKHAG KNHVVSVAWL SK