ID   TDA2_KLULA              Reviewed;         118 AA.
AC   Q6CU41;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Topoisomerase I damage affected protein 2;
GN   Name=TDA2; OrderedLocusNames=KLLA0C07821g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40045}. Cell
CC       projection {ECO:0000250|UniProtKB:P40045}. Note=Concentrates at
CC       cytoplasmic punctate structures and localizes at the mating projection
CC       tip. {ECO:0000250|UniProtKB:P40045}.
CC   -!- SIMILARITY: Belongs to the TDA2 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01399.1; -; Genomic_DNA.
DR   RefSeq; XP_452548.1; XM_452548.1.
DR   AlphaFoldDB; Q6CU41; -.
DR   SMR; Q6CU41; -.
DR   EnsemblFungi; CAH01399; CAH01399; KLLA0_C07821g.
DR   GeneID; 2892492; -.
DR   KEGG; kla:KLLA0_C07821g; -.
DR   eggNOG; ENOG502SFEV; Eukaryota.
DR   HOGENOM; CLU_137494_1_0_1; -.
DR   InParanoid; Q6CU41; -.
DR   OMA; ISVVWIS; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR038586; Tctex-1-like_sf.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Reference proteome.
FT   CHAIN           1..118
FT                   /note="Topoisomerase I damage affected protein 2"
FT                   /id="PRO_0000410731"
SQ   SEQUENCE   118 AA;  13124 MW;  AF72005AE2E57BF6 CRC64;
     MTSSIKITDN SRELNGPVSR EKLSSILNEI FNKDEPIPSS VELVLAQLNE LSSKHKFIVN
     VTKLNANNVN TADFSVDSYI GSSWNDKSDG AFHYQIPLGS GQPDTKRILL VSVYWILL