ID   TDA2_LACTC              Reviewed;         114 AA.
AC   C5DBR4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Topoisomerase I damage affected protein 2;
GN   Name=TDA2; OrderedLocusNames=KLTH0A04752g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40045}. Cell
CC       projection {ECO:0000250|UniProtKB:P40045}. Note=Concentrates at
CC       cytoplasmic punctate structures and localizes at the mating projection
CC       tip. {ECO:0000250|UniProtKB:P40045}.
CC   -!- SIMILARITY: Belongs to the TDA2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAR21221.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CU928165; CAR21221.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002551663.1; XM_002551617.1.
DR   AlphaFoldDB; C5DBR4; -.
DR   SMR; C5DBR4; -.
DR   STRING; 559295.C5DBR4; -.
DR   EnsemblFungi; CAR21221; CAR21221; KLTH0A04752g.
DR   GeneID; 8290467; -.
DR   KEGG; lth:KLTH0A04752g; -.
DR   eggNOG; ENOG502S7YH; Eukaryota.
DR   HOGENOM; CLU_137494_1_0_1; -.
DR   InParanoid; C5DBR4; -.
DR   OrthoDB; 1474572at2759; -.
DR   Proteomes; UP000002036; Chromosome A.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Reference proteome.
FT   CHAIN           1..114
FT                   /note="Topoisomerase I damage affected protein 2"
FT                   /id="PRO_0000410732"
SQ   SEQUENCE   114 AA;  11951 MW;  9C38C8D4E2665F13 CRC64;
     MPALEVNSVP SSSEFPVAPE KLASIIETSA RDASSDDLGA CTESILVELS KASSAHKFVV
     SLTKVAFSDS EDFNLSIDSS IGGSWNKTKD GGYSHSVETE AGARLLATVV WVSK