ID   TDA2_VANPO              Reviewed;         121 AA.
AC   A7TTT7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Topoisomerase I damage affected protein 2;
GN   Name=TDA2; ORFNames=Kpol_147p1;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40045}. Cell
CC       projection {ECO:0000250|UniProtKB:P40045}. Note=Concentrates at
CC       cytoplasmic punctate structures and localizes at the mating projection
CC       tip. {ECO:0000250|UniProtKB:P40045}.
CC   -!- SIMILARITY: Belongs to the TDA2 family. {ECO:0000305}.
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DR   EMBL; DS480624; EDO14318.1; -; Genomic_DNA.
DR   RefSeq; XP_001642176.1; XM_001642126.1.
DR   AlphaFoldDB; A7TTT7; -.
DR   SMR; A7TTT7; -.
DR   STRING; 436907.A7TTT7; -.
DR   EnsemblFungi; EDO14318; EDO14318; Kpol_147p1.
DR   GeneID; 5542289; -.
DR   KEGG; vpo:Kpol_147p1; -.
DR   eggNOG; ENOG502S7YH; Eukaryota.
DR   HOGENOM; CLU_137494_1_0_1; -.
DR   InParanoid; A7TTT7; -.
DR   OMA; ITIIWIS; -.
DR   OrthoDB; 1474572at2759; -.
DR   PhylomeDB; A7TTT7; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR005334; Tctex-1-like.
DR   InterPro; IPR038586; Tctex-1-like_sf.
DR   Pfam; PF03645; Tctex-1; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Topoisomerase I damage affected protein 2"
FT                   /id="PRO_0000410733"
SQ   SEQUENCE   121 AA;  13794 MW;  CE218F2509477E92 CRC64;
     MNVEIGNRSL DNENSPIPKE KLTTLIDEVY GERKEKSDFT YNNLIQGILE GLNKHSSFYK
     YIVTVTDVQN KQSGSNDFEL EHYFGASWSS KKDGLFQYCL PSEEDTSSQS VVTIVWISKS
     I