ID   TDA2_YEAS8              Reviewed;         126 AA.
AC   C8Z779;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Topoisomerase I damage affected protein 2;
GN   Name=TDA2; ORFNames=EC1118_1E8_1871g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40045}. Cell
CC       projection {ECO:0000250|UniProtKB:P40045}. Note=Concentrates at
CC       cytoplasmic punctate structures and localizes at the mating projection
CC       tip. {ECO:0000250|UniProtKB:P40045}.
CC   -!- SIMILARITY: Belongs to the TDA2 family. {ECO:0000305}.
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DR   EMBL; FN393067; CAY79245.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8Z779; -.
DR   SMR; C8Z779; -.
DR   EnsemblFungi; CAY79245; CAY79245; EC1118_1E8_1871g.
DR   HOGENOM; CLU_137494_1_0_1; -.
DR   Proteomes; UP000000286; Chromosome V, Scaffold EC1118_1E8.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.1140.40; -; 1.
DR   InterPro; IPR005334; Tctex-1-like.
DR   InterPro; IPR038586; Tctex-1-like_sf.
DR   Pfam; PF03645; Tctex-1; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell projection; Cytoplasm.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P40045"
FT   CHAIN           2..126
FT                   /note="Topoisomerase I damage affected protein 2"
FT                   /id="PRO_0000410737"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40045"
SQ   SEQUENCE   126 AA;  14471 MW;  2F5CD27AF0D386E3 CRC64;
     MSMQIEIKDG RSDNSPLPER KLVTLIQESY DSLKDDNEIN LSTESTSNLL IKLVLEKLEK
     HSSLYKYIAS VTTLNIEGLN EENANFSLKN DIGASWESKK DGIFNYKLED KNSNECYLIT
     ILWLHK