ID   TDA7_CANGA              Reviewed;         629 AA.
AC   Q6FNJ6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Topoisomerase I damage affected protein 7;
GN   Name=TDA7; OrderedLocusNames=CAGL0J11176g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDA7 family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG61149.1; -; Genomic_DNA.
DR   RefSeq; XP_448198.1; XM_448198.1.
DR   AlphaFoldDB; Q6FNJ6; -.
DR   SMR; Q6FNJ6; -.
DR   STRING; 5478.XP_448198.1; -.
DR   EnsemblFungi; CAG61149; CAG61149; CAGL0J11176g.
DR   GeneID; 2889488; -.
DR   KEGG; cgr:CAGL0J11176g; -.
DR   CGD; CAL0133688; CAGL0J11176g.
DR   VEuPathDB; FungiDB:CAGL0J11176g; -.
DR   eggNOG; ENOG502S5S1; Eukaryota.
DR   HOGENOM; CLU_029057_0_0_1; -.
DR   InParanoid; Q6FNJ6; -.
DR   OMA; FYQHWLD; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0062040; C:fungal biofilm matrix; IDA:CGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Vacuole.
FT   CHAIN           1..629
FT                   /note="Topoisomerase I damage affected protein 7"
FT                   /id="PRO_0000410745"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          365..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          591..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..610
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        249
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        315
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        333
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        478
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   629 AA;  67352 MW;  E3BD8A0D0B665207 CRC64;
     MIHNSSYTEA ADIKSLSSFI EESSRVPDYI SESNNIGWSS NINNPPLFES SSFDITTQND
     NWILTETMQN ITTESSSTFS RSVASSVFPS SSQAFVSPPS IIDIPISSIP ESSSISISSD
     VLSSAITVSQ TSSSSYSSLI SSYSTIQSTS SSSISENEIS SSSRISPGLL SSVPSITTSF
     SSGISSSVSP TSSLQQIAEQ SSNSSLAEND LLSSSLTILS SVLSSSVLLH NSGVSSSSFT
     DNFSSTLTNS SNSLAILSSI SESSLINTIT DLPSSSVLLS PNNSESSIKV SSASSSSSRR
     KASTYTTPSR IPFSNSSEWY TPLPTPSISS STNDTSSLLS ELALIGISSS SSSSSSSQFY
     TSSTSSSSLV SSSENYSSSQ PTTIEPITST ISSSYSDLSN DGEILSSTLG KSVYYSYIQT
     FDITASTTTF ETALPIVTAF NLKDSYTFSK PSSIITTDLH FYKDWLSGAL DSNEENGNKS
     KNAGTIAGSV VGSVVGLLVC TLIVWYFYIR KRRRNQKWKS FEVPSRSKDV EYNNNDNPFN
     NEFDFQHRVP PPLPPQRKNH NSIGVPPSSM GLSNTRSADY HMRFSYISSS TDSSDDYSDS
     MQSALHIGSD SGRERSNDVP EMGYLREII