ID   BR1S_ODOSH              Reviewed;          70 AA.
AC   Q2UXV9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Brevinin-1S;
DE   Flags: Precursor;
OS   Odorrana schmackeri (Schmacker's frog) (Rana schmackeri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=110116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=16139929; DOI=10.1016/j.peptides.2005.06.024;
RA   Chen T., Li L., Zhou M., Rao P., Walker B., Shaw C.;
RT   "Amphibian skin peptides and their corresponding cDNAs from
RT   singlelyophilized secretion samples: identification of novel brevinins
RT   fromthree species of Chinese frogs.";
RL   Peptides 27:42-48(2006).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   EMBL; AJ971790; CAI96773.1; -; mRNA.
DR   AlphaFoldDB; Q2UXV9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012520; Antimicrobial_frog_1.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF08018; Antimicrobial_1; 1.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..44
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000268225"
FT   PEPTIDE         47..70
FT                   /note="Brevinin-1S"
FT                   /id="PRO_0000268226"
FT   DISULFID        64..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  8041 MW;  FB5A718E00A9AA79 CRC64;
     MFTLKKSLLL LFFLGTINLS LCEEERNAEE ERRDDPEERD VEVEKRFFPA ILRVAAKVGP
     AVLCAITKKC