ID   TDA7_YEASO              Reviewed;         636 AA.
AC   E7NM81;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   29-SEP-2021, entry version 32.
DE   RecName: Full=Topoisomerase I damage affected protein 7;
GN   Name=TDA7; ORFNames=FOSTERSO_3962;
OS   Saccharomyces cerevisiae (strain FostersO) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=764101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FostersO;
RX   PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA   Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA   Pretorius I.S., Egholm M., Chambers P.J.;
RT   "Whole-genome comparison reveals novel genetic elements that characterize
RT   the genome of industrial strains of Saccharomyces cerevisiae.";
RL   PLoS Genet. 7:E1001287-E1001287(2011).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDA7 family. {ECO:0000305}.
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DR   EMBL; AEEZ01000083; EGA60795.1; -; Genomic_DNA.
DR   EnsemblFungi; EGA60795; EGA60795; FOSTERSO_3962.
DR   HOGENOM; CLU_029057_0_0_1; -.
DR   OMA; FYQHWLD; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Glycoprotein; Isopeptide bond; Membrane; Phosphoprotein; Transmembrane;
KW   Transmembrane helix; Ubl conjugation; Vacuole.
FT   CHAIN           1..636
FT                   /note="Topoisomerase I damage affected protein 7"
FT                   /id="PRO_0000410752"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          506..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..542
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         628
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53882"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        492
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        557
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        562
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        626
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CROSSLNK        512
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:P53882"
SQ   SEQUENCE   636 AA;  67395 MW;  8611C408C03B37F8 CRC64;
     MNSNSTIGRT TLGESDTISL SFSEPSSSLN SRSTDVVFAS TSTLVPQQGS LTSLPPVSST
     ATPTYYSTSL TYDETLHTSI DVSSTSTLVS STDSSSSSEQ DTYSSQYDPA TSSYSIITPS
     MSIFSSTSPM SSSSSITSEW SSLTSTTPTL SXSATSLSSS WSSLSSPSSL LVSSSLSLSL
     SSSYSDTKLF SFDSRSSIFS PSTPTVISPS YTYLSSISAT SFQISTTSEL SXSWFSTISS
     PSTTSNKDTT FPSSSRNTST SFYSSSLSST NDFSTISKSS KLSPSASSST VSISTISVPT
     SSSVSSSSSK VPSNRPSSSS SSDDTTSAYS STYTFQSLQS TTSSSIPPXT QTPSTSTIST
     SPIPTSSQVF NTXAISSSED SKTIYYFYTQ TYDITDSSTT FVTGLPTTIA VAKSEVTSFS
     APSSTITADM SFYQHWLDGS LDNNKNQGTS KTNTGTIVGS VVGSVGGILI CVLVVWFMLV
     RKRKAKRHFK ENDSFCHEIG RRTGFPTTAQ AKEASLQAQD SGSQQRNTET ASANNPFSNE
     FNFKARGNPP PVPPPRNVTA XNGSFQNMRS NFMDQENRFS YGSSFTYSSL GSSTQGGFST
     LSSNSIRLGX GLDNDISHDE RNTVQNNSQG FLREII