ID   TDCA_ECO57              Reviewed;         312 AA.
AC   P0ACQ8; P11036;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=HTH-type transcriptional regulator TdcA;
DE   AltName: Full=Tdc operon transcriptional activator;
GN   Name=tdcA; OrderedLocusNames=Z4470, ECs3998;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Transcriptional activator for the tdcABCDE operon.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid degradation; L-threonine degradation via propanoate
CC       pathway [regulation].
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG58249.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37421.1; -; Genomic_DNA.
DR   PIR; E85973; E85973.
DR   PIR; F91128; F91128.
DR   RefSeq; NP_312025.1; NC_002695.1.
DR   RefSeq; WP_000104211.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACQ8; -.
DR   SMR; P0ACQ8; -.
DR   STRING; 155864.EDL933_4339; -.
DR   EnsemblBacteria; AAG58249; AAG58249; Z4470.
DR   EnsemblBacteria; BAB37421; BAB37421; ECs_3998.
DR   GeneID; 66672981; -.
DR   GeneID; 916165; -.
DR   KEGG; ece:Z4470; -.
DR   KEGG; ecs:ECs_3998; -.
DR   PATRIC; fig|386585.9.peg.4172; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OMA; PQTDMGY; -.
DR   UniPathway; UPA00052; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0070689; P:L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..312
FT                   /note="HTH-type transcriptional regulator TdcA"
FT                   /id="PRO_0000105758"
FT   DOMAIN          7..64
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  34539 MW;  1ADD366D71ED68AB CRC64;
     MSTILLPKTQ HLVVFQEVIR SGSIGSAAKE LGLTQPAVSK IINDIEDYFG VELVVRKNTG
     VTLTPAGQLL LSRSESITRE MKNMVNEISG MSSEAVVEVS FGFPSLIGFT FMSGMINKFK
     EVFPKAQVSM YEAQLSSFLP AIRDGRLDFA IGTLSAEMKL QDLHVEPLFE SEFVLVASKS
     RTCTGTTTLE SLKNEQWVLP QTNMGYYSEL LTTLQRNGIS IENIVKTDSV VTIYNLVLNA
     DFLTVIPCDM TSPFGSNQFI TIPVEETLPV AQYAAVWSKN YRIKKAASVL VELAKEYSSY
     NGCRRRQLIE VG