TDCA_ECOLI
ID TDCA_ECOLI Reviewed; 312 AA.
AC P0ACQ7; P11036; Q2M989;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=HTH-type transcriptional regulator TdcA;
DE AltName: Full=Tdc operon transcriptional activator;
GN Name=tdcA; OrderedLocusNames=b3118, JW3089;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3003533; DOI=10.1007/bf00425676;
RA Goss T.J., Datta P.;
RT "Molecular cloning and expression of the biodegradative threonine
RT dehydratase gene (tdc) of Escherichia coli K12.";
RL Mol. Gen. Genet. 201:308-314(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2660107; DOI=10.1093/nar/17.10.3994;
RA Schweizer H., Datta P.;
RT "The complete nucleotide sequence of the tdc region of Escherichia coli.";
RL Nucleic Acids Res. 17:3994-3994(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-215.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=10520749; DOI=10.3109/10425179809072194;
RA Hesslinger C., Sawers G.;
RT "The tdcE gene in Escherichia coli strain W3110 is separated from the rest
RT of the tdc operon by insertion of IS5 elements.";
RL DNA Seq. 9:183-188(1998).
RN [6]
RP FUNCTION.
RX PubMed=8413189; DOI=10.1007/bf00280391;
RA Ganduri Y.L., Sadda S.R., Datta M.W., Jambukeswaran R.K., Datta P.;
RT "TdcA, a transcriptional activator of the tdcABC operon of Escherichia
RT coli, is a member of the LysR family of proteins.";
RL Mol. Gen. Genet. 240:395-402(1993).
CC -!- FUNCTION: Transcriptional activator for the tdcABCDE operon.
CC {ECO:0000269|PubMed:8413189}.
CC -!- PATHWAY: Amino-acid degradation; L-threonine degradation via propanoate
CC pathway [regulation].
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; M21312; AAA24659.1; -; Genomic_DNA.
DR EMBL; X14430; CAA32592.1; -; Genomic_DNA.
DR EMBL; U18997; AAA57922.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76153.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77167.1; -; Genomic_DNA.
DR EMBL; AJ001620; CAA04873.1; -; Genomic_DNA.
DR PIR; S46415; QQECRG.
DR RefSeq; NP_417588.1; NC_000913.3.
DR RefSeq; WP_000104211.1; NZ_STEB01000001.1.
DR AlphaFoldDB; P0ACQ7; -.
DR SMR; P0ACQ7; -.
DR BioGRID; 4262420; 7.
DR DIP; DIP-10968N; -.
DR IntAct; P0ACQ7; 3.
DR STRING; 511145.b3118; -.
DR PaxDb; P0ACQ7; -.
DR PRIDE; P0ACQ7; -.
DR EnsemblBacteria; AAC76153; AAC76153; b3118.
DR EnsemblBacteria; BAE77167; BAE77167; BAE77167.
DR GeneID; 66672981; -.
DR GeneID; 947494; -.
DR KEGG; ecj:JW3089; -.
DR KEGG; eco:b3118; -.
DR PATRIC; fig|1411691.4.peg.3612; -.
DR EchoBASE; EB0982; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_0_6; -.
DR OMA; PQTDMGY; -.
DR PhylomeDB; P0ACQ7; -.
DR BioCyc; EcoCyc:PD00268; -.
DR UniPathway; UPA00052; -.
DR PRO; PR:P0ACQ7; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IDA:EcoCyc.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0070689; P:L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..312
FT /note="HTH-type transcriptional regulator TdcA"
FT /id="PRO_0000105757"
FT DOMAIN 7..64
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 24..43
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT CONFLICT 3
FT /note="T -> A (in Ref. 1; AAA24659)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34539 MW; 1ADD366D71ED68AB CRC64;
MSTILLPKTQ HLVVFQEVIR SGSIGSAAKE LGLTQPAVSK IINDIEDYFG VELVVRKNTG
VTLTPAGQLL LSRSESITRE MKNMVNEISG MSSEAVVEVS FGFPSLIGFT FMSGMINKFK
EVFPKAQVSM YEAQLSSFLP AIRDGRLDFA IGTLSAEMKL QDLHVEPLFE SEFVLVASKS
RTCTGTTTLE SLKNEQWVLP QTNMGYYSEL LTTLQRNGIS IENIVKTDSV VTIYNLVLNA
DFLTVIPCDM TSPFGSNQFI TIPVEETLPV AQYAAVWSKN YRIKKAASVL VELAKEYSSY
NGCRRRQLIE VG
